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- W4232000770 abstract "Abstract Objective: Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD). We aimed to disclose if there is an association between ficolin-3 ( FCN3) gene polymorphisms (rs4494157 and rs10794501) and RF with or without RHD for the first time in Egyptian adolescents. Results: Serum ficolin-3 level was significantly elevated in patients suffering from RF with and without RHD in comparison with control. Regarding FCN3 gene (rs4494157) polymorphism, a significant correlation was found between the A allele and the susceptibility to RF with or without RHD (OR=2.93, P =0.0002 and OR=2.23, P =0.008 respectively). Besides, AA homozygous genotype showed a significant association with RHD risk (OR=3.47, P =0.026). Patients carrying the A allele (CA+AA) had significantly higher serum ficolin-3 than those carrying the CC genotype ( P ˂ 0.0001). While the frequency of (rs10794501) polymorphism revealed no significant differences between the controls and RF patients with or without RHD (OR=1.43, P =0.261 and OR=1.48, P =0.208 respectively)." @default.
- W4232000770 created "2022-05-12" @default.
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- W4232000770 date "2020-12-30" @default.
- W4232000770 modified "2023-09-26" @default.
- W4232000770 title "The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents Study" @default.
- W4232000770 doi "https://doi.org/10.21203/rs.3.rs-54221/v1" @default.
- W4232000770 hasPublicationYear "2020" @default.
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