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- W4232072022 abstract "The effects of anti-vertigo drugs on medial vestibular nucleus (MVN) neurons were examined to assess the site and mode of action using cats anesthetized with α-chloralose. Single neuron activity in the MVN was extracellulariy recorded using a silver wire microelectrode attached along a seven-barreled micropipette, each of which was filled with diphenhydramine, diphenidol, betahistine, glutamate or NaCI. Type 1 of the MVN neurons were identified according to the responses obtained when the animal placed on a turn-table was rotated sinusoidally. The effects of the drugs were examined on type I neurons which received impulses primarily from the labyrinth and sent them to the oculomotor nuclei. The microiontophoretic application of diphenhydramine, diphenidol and betahistine inhibited rotation-induced firing of type I MVN neurons. Diphenhydramine and diphenidol were more potent than betahistine. These results suggest that these drugs directly act on MVN neurons to reduce the responsiveness to rotatory stimulation." @default.
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- W4232072022 date "1991-01-01" @default.
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- W4232072022 title "Effects of Anti-Vertigo Drugs on Medial Vestibular Nucleus Neurons Activated by Horizontal Rotation" @default.
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- W4232072022 doi "https://doi.org/10.1016/s0021-5198(19)39982-2" @default.
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