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• W4232111657 abstract "Abstract Background : Whether the metabolically healthy obese (MHO) phenotype is a single, stable or a transitional, fluctuating state is currently unknown. The Mexican-Mestizo population has a genetic predisposition for the development of type 2 diabetes and other cardiometabolic complications. Little is known about the natural history of metabolic health in this population. The aim of this study was to analyze the transitions over time among individuals with different degrees of metabolic health and body mass index, and evaluate the incidence of cardiometabolic outcomes according to phenotype. Methods: The study population consisted of a metabolic syndrome cohort with at least three years of follow up. Participants were apparently-healthy urban Mexican adults ≥ 20 years with a BMI ≥ 20 kg/m2. Metabolically healthy phenotype was defined using the criteria of the NECP ATP III metabolic syndrome criteria and the subjects were stratified into 4 groups according to their BMI and metabolic health. For cardiometabolic outcomes we estimated the incidence of cardiometabolic outcomes and standardized them per 1, 000 person-years of follow-up. Finally, to evaluate the risk for transition and development of cardiometabolic outcomes, we fitted Cox Proportional Hazard regression models. Results : Amongst the 5,541 subjects, 54.2% were classified as metabolically healthy and 45.8% as unhealthy. The MHO prevalence was 39.3%. Up to a third of the population changed from their initial category to another and the higher transition rate was observed in MHO (42.9%). We also found several novel factors associated to transition to metabolically unhealthy phenotype; socioeconomic status, number of pregnancies, a high carbohydrate intake, history of obesity and consumption of sweetened beverages. Similarly, visceral adipose tissue (VAT) was a main predictor of transition; loss of VAT ≥5% was associated with reversion from metabolically unhealthy to metabolically healthy phenotype (HR 1.545, 95%CI 1.266–1.886). Finally, we observed higher incidence rates and risk of incident T2D and hypertension in the MUHO and MUHL phenotypes compared to MHO. Conclusions Metabolic health is a dynamic and continuous process, at high risk of transition to metabolically unhealthy phenotypes over time. It is imperative to establish effective processes in primary care to prevent such transitions." @default.
• W4232111657 created "2022-05-12" @default.
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• W4232111657 date "2020-11-20" @default.
• W4232111657 modified "2023-09-29" @default.
• W4232111657 title "Natural Course of Metabolically Healthy Phenotype and Risk of Developing Cardiometabolic Diseases: a three years follow-up study" @default.
• W4232111657 doi "https://doi.org/10.21203/rs.3.rs-108563/v1" @default.
• W4232111657 hasPublicationYear "2020" @default.
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