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- W4232128579 abstract "Abstract A metal‐free regio‐ and stereocontrolled group‐transfer route toward the synthesis of trisubstituted alkenes is described. In this route, an electrophilic heterocyclization is followed by ring‐opening group transfer. Specifically, a thioboration reaction transforms readily available alkynyl sulfide precursors into alkenyl boronates and alkenyl sulfides with defined regio‐ and stereochemistry in one synthetic step using commercially available B ‐chlorocatecholborane (ClBcat). Mechanistic studies identified the likely pathway as proceeding through zwitterionic rather than haloborated intermediates. The regio‐ and stereochemistry set in the initial cyclization step is preserved in the final acyclic alkene product, producing alkenes with up to four modifiable substituents with predictable regio‐ and stereochemistry. Downstream functionalization reactions showcase the versatility of the substitutions of the resulting alkenes. The mechanistic concept maps onto future reaction designs, given the abundance of known electrophiles and nucleophiles for electrophilic heterocyclization/dealkylation sequences." @default.
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- W4232128579 date "2021-10-29" @default.
- W4232128579 modified "2023-10-16" @default.
- W4232128579 title "Repurposing π Electrophilic Cyclization/Dealkylation for Group Transfer" @default.
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- W4232128579 doi "https://doi.org/10.1002/ange.202112351" @default.
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