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- W4232135305 abstract "F-BAR proteins are prime candidates to regulate membrane curvature and dynamics during different developmental processes. Here, we analyzed nostrin (nost), a novel Drosophila F-BAR protein related to Cip4. Genetic analyses revealed a strong synergism between nost and cip4 functions. While single mutant flies are viable and fertile, combined loss of nost and cip4 results in reduced viability and fertility. Double mutant escaper flies show enhanced wing polarization defects and females exhibit strong egg chamber encapsulation defects. Live-imaging analysis suggests that the observed phenotypes are caused by an impaired E-cadherin membrane turnover. Simultaneous knock-down of Cip4 and Nostrin strongly increases the formation of tubular E-cadherin vesicles at adherens junctions. Cip4 and Nostrin localize at distinct membrane subdomains. Both proteins prefer similar membrane curvatures but seem to form different membrane coats and do not heterooligomerize. Our data suggest an important synergistic function of both F-BAR proteins in membrane dynamics. We propose a cooperative recruitment model in which first Cip4 promotes membrane invagination and early actin-based endosomal motility while Nostrin makes contact with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes." @default.
- W4232135305 created "2022-05-12" @default.
- W4232135305 creator A5004346719 @default.
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- W4232135305 date "2014-01-01" @default.
- W4232135305 modified "2023-09-24" @default.
- W4232135305 title "Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in regulating E-cadherin in epithelial morphogenesis" @default.
- W4232135305 cites W1512863307 @default.
- W4232135305 cites W1554313068 @default.
- W4232135305 cites W1555563809 @default.
- W4232135305 cites W1560333589 @default.
- W4232135305 cites W1572524050 @default.
- W4232135305 cites W1847219014 @default.
- W4232135305 cites W1855259954 @default.
- W4232135305 cites W1948844441 @default.
- W4232135305 cites W1970115525 @default.
- W4232135305 cites W1971634319 @default.
- W4232135305 cites W1972821185 @default.
- W4232135305 cites W1976640184 @default.
- W4232135305 cites W1978666455 @default.
- W4232135305 cites W1979351753 @default.
- W4232135305 cites W1979665736 @default.
- W4232135305 cites W1980333298 @default.
- W4232135305 cites W1981411461 @default.
- W4232135305 cites W1982881611 @default.
- W4232135305 cites W1984815090 @default.
- W4232135305 cites W1990380758 @default.
- W4232135305 cites W1997477896 @default.
- W4232135305 cites W1997970131 @default.
- W4232135305 cites W2004344365 @default.
- W4232135305 cites W2006322284 @default.
- W4232135305 cites W2010015418 @default.
- W4232135305 cites W2012674191 @default.
- W4232135305 cites W2013502070 @default.
- W4232135305 cites W2019660494 @default.
- W4232135305 cites W2024578750 @default.
- W4232135305 cites W2027752523 @default.
- W4232135305 cites W2029162250 @default.
- W4232135305 cites W2034108399 @default.
- W4232135305 cites W2034496001 @default.
- W4232135305 cites W2041455568 @default.
- W4232135305 cites W2041848251 @default.
- W4232135305 cites W2048357384 @default.
- W4232135305 cites W2048463976 @default.
- W4232135305 cites W2049315117 @default.
- W4232135305 cites W2052112605 @default.
- W4232135305 cites W2067958032 @default.
- W4232135305 cites W2069613957 @default.
- W4232135305 cites W2072167784 @default.
- W4232135305 cites W2074133216 @default.
- W4232135305 cites W2078657639 @default.
- W4232135305 cites W2079534879 @default.
- W4232135305 cites W2084399849 @default.
- W4232135305 cites W2091001823 @default.
- W4232135305 cites W2094419120 @default.
- W4232135305 cites W2094803625 @default.
- W4232135305 cites W2098715685 @default.
- W4232135305 cites W2114802325 @default.
- W4232135305 cites W2116373233 @default.
- W4232135305 cites W2116972703 @default.
- W4232135305 cites W2117365121 @default.
- W4232135305 cites W2118496084 @default.
- W4232135305 cites W2120987072 @default.
- W4232135305 cites W2122600997 @default.
- W4232135305 cites W2127096584 @default.
- W4232135305 cites W2128598048 @default.
- W4232135305 cites W2129118686 @default.
- W4232135305 cites W2129548808 @default.
- W4232135305 cites W2131411591 @default.
- W4232135305 cites W2144134765 @default.
- W4232135305 cites W2144996654 @default.
- W4232135305 cites W2152035225 @default.
- W4232135305 cites W2155717027 @default.
- W4232135305 cites W2167852809 @default.
- W4232135305 cites W2170996392 @default.
- W4232135305 cites W2182689882 @default.
- W4232135305 cites W2185119839 @default.
- W4232135305 cites W2293990541 @default.
- W4232135305 doi "https://doi.org/10.1242/jcs.155929" @default.
- W4232135305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25413347" @default.
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