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- W4232143807 abstract "Background:Adequate intake of lutein is postulated to reduce the risk of age-related macular degeneration, but kinetic information for developing a dosing regimen is sparse. Objective:The objective was to characterize lutein plasma kinetics in a multiple dosing design and to assess the effects of lutein intake on concentrations of other plasma carotenoids. Design:After a run-in period of 7 d, 19 healthy volunteers were assigned to receive daily oral doses of 4.1 mg lutein (n = 8; group 1) or 20.5 mg lutein (n = 8; group 2) for 42 d or no lutein (n = 3; control group). The supplement contained 8.3% zeaxanthin relative to lutein (100%). The time profiles of plasma xanthophyll concentrations were monitored over the dosing phase, and samples were collected frequently on day 42 and for 24 d after dosing. Results:Average plasma all-E-lutein concentrations increased from 0.14 to 0.52 ± 0.13 and 1.45 ± 0.69 μmol/L in groups 1 and 2, respectively. Dose-normalized lutein bioavailability in group 2 was ≈60% of that in group 1. Kinetic disposition half-life did not differ significantly between groups. On average, dosing for 18 d was required to reach a >90% fraction of the steady state concentration, which is consistent with an effective half-life for accumulation of ≈5.6 d. Plasma kinetics of all-E-lutein were paralleled by those of all-E-3-dehydro-lutein. Kinetic analysis indicated formation of all-E-3-dehydro-lutein from lutein. Lutein was well tolerated and did not affect the concentrations of other carotenoids. Conclusion:Long-term supplementation with 4.1 and 20.5 mg lutein as beadlets increased plasma lutein concentrations ≈3.5- and 10-fold, respectively." @default.
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- W4232143807 date "2005-07-01" @default.
- W4232143807 modified "2023-09-29" @default.
- W4232143807 title "Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement" @default.
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- W4232143807 doi "https://doi.org/10.1093/ajcn/82.1.88" @default.
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