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- W4232168382 abstract "This chapter discusses adverse effects of miscellaneous hormones and prostaglandins. Long-term human growth hormone (hGH) treatment or replacement increases the pattern of adverse effects. In children, problems associated with fluid retention are less common than in adults; however musculoskeletal problems, such as slipped epiphyses, kyphoscoliosis are more common. There is a higher frequency of adverse effects in children who had been previously treated for leukemia and craniopharyngioma and lower rates in those treated for idiopathic short stature. Benign intracranial hypertension, associated with papilledema, remains the most significant subacute onset effect. In adults with hypopituitarism, hGH is associated with an 18% incidence of adverse effects related to fluid retention during the first 2 months of treatment. A higher incidence of adverse effects may be predicted by age, greater body mass index, better pre-treatment GH reserve, and a supraphysiological response of insulin-like growth factor I to initial treatment. Acute adverse effects of recombinant human insulin-like growth factor I (IGF-I) include hypoglycemia, which is dose related, and fluid retention at days 3–4." @default.
- W4232168382 created "2022-05-12" @default.
- W4232168382 creator A5015883651 @default.
- W4232168382 date "1997-01-01" @default.
- W4232168382 modified "2023-09-25" @default.
- W4232168382 title "Miscellaneous hormones and prostaglandins" @default.
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- W4232168382 doi "https://doi.org/10.1016/s0378-6080(05)80405-2" @default.
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