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- W4232169143 abstract "Abstract If pathogen species, strains or clones do not interact, intuition suggests the proportion of co-infected hosts should be the product of the individual prevalences. Independence consequently underpins the wide range of methods for detecting pathogen interactions from cross-sectional survey data. However, the very simplest of epidemiological models challenge the underlying assumption of statistical independence. Even if pathogens do not interact, death of co-infected hosts causes net prevalences of individual pathogens to decrease simultaneously. The induced positive correlation between prevalences means the proportion of co-infected hosts is expected to be higher than multiplication would suggest. By modeling the dynamics of multiple non-interacting pathogens, we develop a pair of novel tests of interaction that properly account for non-independence. Our tests allow us to reinterpret data from previous studies including pathogens of humans, plants, and animals. Our work demonstrates how methods to identify interactions between pathogens can be updated using simple epidemic models." @default.
- W4232169143 created "2022-05-12" @default.
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- W4232169143 date "2019-04-26" @default.
- W4232169143 modified "2023-10-03" @default.
- W4232169143 title "Co-infections by non-interacting pathogens are not independent & require new tests of interaction" @default.
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- W4232169143 doi "https://doi.org/10.1101/618900" @default.
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