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• W4232186152 endingPage "7978" @default.
• W4232186152 startingPage "7972" @default.
• W4232186152 abstract "Abstract Proof‐of‐concept is provided that a large estate of 16‐membered macrolide antibiotics can be reached by a “unified” approach. The key building block was formed on scale by an asymmetric vinylogous Mukaiyama aldol reaction; its alkene terminus was then converted either into the corresponding methyl ketone by Wacker oxidation or into a chain‐extended aldehyde by catalyst‐controlled branch‐selective asymmetric hydroformylation. These transformations ultimately opened access to two structurally distinct series of macrolide targets. Notable late‐stage maneuvers comprise a rare example of a ruthenium‐catalyzed redox isomerization of an 1,3‐enyne‐5‐ol into a 1,3‐diene‐5‐one derivative, as well as the elaboration of a tertiary propargylic alcohol into an acyloin by trans ‐hydrostannation/Chan‐Lam‐type coupling. Moreover, this case study illustrates the underutilized possibility of forging complex macrolactone rings by transesterification under essentially neutral conditions." @default.
• W4232186152 created "2022-05-12" @default.
• W4232186152 creator A5000031419 @default.
• W4232186152 creator A5037494680 @default.
• W4232186152 creator A5046690920 @default.
• W4232186152 creator A5054667122 @default.
• W4232186152 date "2021-02-26" @default.
• W4232186152 modified "2023-10-09" @default.
• W4232186152 title "Total Synthesis of Mycinolide IV and Path‐Scouting for Aldgamycin N" @default.
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