Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232189731> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4232189731 endingPage "545" @default.
- W4232189731 startingPage "545" @default.
- W4232189731 abstract "Indicator dilution theory predicts that the first-pass pulmonary and systemic arterial concentrations of a drug will be inversely related to the cardiac output. For high-clearance drugs, these first-pass concentrations may contribute significantly to the measured arterial concentrations, which would therefore also be inversely related to cardiac output. We examined the cardiac output dependence of the initial kinetics of propofol in two separate studies using chronically instrumented sheep in which propofol (100 mg) was infused IV over 2 min. In the first study, steady-state periods of low, medium, and high cardiac output were achieved by altering carbon dioxide tension in six halothane-anesthetized sheep. The initial area under the curve and peak value of the pulmonary artery propofol concentrations were inversely related to cardiac output (R2 = 0.57 and 0.66, respectively). For the systemic arterial concentrations, these R2 values were 0.68 and 0.71, respectively. In our second study, transient reductions in cardiac output were achieved in five conscious sheep by administering a short infusion of metaraminol concurrently with propofol. Cardiac output was lowered by 2.2 L/min, and the area under the curve to 10 min of the arterial concentrations increased to 143% of control. Implications The initial arterial concentrations of propofol after IV administration were shown to be inversely related to cardiac output. This implies that cardiac output may be a determinant of the induction of anesthesia with propofol." @default.
- W4232189731 created "2022-05-12" @default.
- W4232189731 creator A5004722292 @default.
- W4232189731 creator A5028000845 @default.
- W4232189731 creator A5029474815 @default.
- W4232189731 creator A5080848550 @default.
- W4232189731 date "1999-09-01" @default.
- W4232189731 modified "2023-10-11" @default.
- W4232189731 title "Cardiac Output is a Determinant of the Initial Concentrations of Propofol After Short-Infusion Administration" @default.
- W4232189731 cites W1556982405 @default.
- W4232189731 cites W1965271478 @default.
- W4232189731 cites W1988851560 @default.
- W4232189731 cites W2003547478 @default.
- W4232189731 cites W2012325157 @default.
- W4232189731 cites W2038520956 @default.
- W4232189731 cites W2066079201 @default.
- W4232189731 cites W2074433247 @default.
- W4232189731 cites W2078668923 @default.
- W4232189731 cites W2081757067 @default.
- W4232189731 cites W2092963024 @default.
- W4232189731 cites W2106212678 @default.
- W4232189731 cites W2108275197 @default.
- W4232189731 cites W2110220534 @default.
- W4232189731 cites W2130130081 @default.
- W4232189731 cites W2154553073 @default.
- W4232189731 cites W240539887 @default.
- W4232189731 doi "https://doi.org/10.1213/00000539-199909000-00002" @default.
- W4232189731 hasPublicationYear "1999" @default.
- W4232189731 type Work @default.
- W4232189731 citedByCount "73" @default.
- W4232189731 countsByYear W42321897312012 @default.
- W4232189731 countsByYear W42321897312013 @default.
- W4232189731 countsByYear W42321897312014 @default.
- W4232189731 countsByYear W42321897312015 @default.
- W4232189731 countsByYear W42321897312016 @default.
- W4232189731 countsByYear W42321897312017 @default.
- W4232189731 countsByYear W42321897312018 @default.
- W4232189731 countsByYear W42321897312019 @default.
- W4232189731 countsByYear W42321897312020 @default.
- W4232189731 countsByYear W42321897312021 @default.
- W4232189731 countsByYear W42321897312022 @default.
- W4232189731 countsByYear W42321897312023 @default.
- W4232189731 crossrefType "journal-article" @default.
- W4232189731 hasAuthorship W4232189731A5004722292 @default.
- W4232189731 hasAuthorship W4232189731A5028000845 @default.
- W4232189731 hasAuthorship W4232189731A5029474815 @default.
- W4232189731 hasAuthorship W4232189731A5080848550 @default.
- W4232189731 hasConcept C126322002 @default.
- W4232189731 hasConcept C139940330 @default.
- W4232189731 hasConcept C164705383 @default.
- W4232189731 hasConcept C178853913 @default.
- W4232189731 hasConcept C2776119275 @default.
- W4232189731 hasConcept C2776277131 @default.
- W4232189731 hasConcept C2776932660 @default.
- W4232189731 hasConcept C2778789114 @default.
- W4232189731 hasConcept C2779537118 @default.
- W4232189731 hasConcept C42219234 @default.
- W4232189731 hasConcept C71924100 @default.
- W4232189731 hasConcept C84393581 @default.
- W4232189731 hasConceptScore W4232189731C126322002 @default.
- W4232189731 hasConceptScore W4232189731C139940330 @default.
- W4232189731 hasConceptScore W4232189731C164705383 @default.
- W4232189731 hasConceptScore W4232189731C178853913 @default.
- W4232189731 hasConceptScore W4232189731C2776119275 @default.
- W4232189731 hasConceptScore W4232189731C2776277131 @default.
- W4232189731 hasConceptScore W4232189731C2776932660 @default.
- W4232189731 hasConceptScore W4232189731C2778789114 @default.
- W4232189731 hasConceptScore W4232189731C2779537118 @default.
- W4232189731 hasConceptScore W4232189731C42219234 @default.
- W4232189731 hasConceptScore W4232189731C71924100 @default.
- W4232189731 hasConceptScore W4232189731C84393581 @default.
- W4232189731 hasIssue "3" @default.
- W4232189731 hasLocation W42321897311 @default.
- W4232189731 hasOpenAccess W4232189731 @default.
- W4232189731 hasPrimaryLocation W42321897311 @default.
- W4232189731 hasRelatedWork W1837865364 @default.
- W4232189731 hasRelatedWork W1985858036 @default.
- W4232189731 hasRelatedWork W2011107836 @default.
- W4232189731 hasRelatedWork W2130684931 @default.
- W4232189731 hasRelatedWork W2327387970 @default.
- W4232189731 hasRelatedWork W2354276920 @default.
- W4232189731 hasRelatedWork W2369770283 @default.
- W4232189731 hasRelatedWork W2405416670 @default.
- W4232189731 hasRelatedWork W2428256220 @default.
- W4232189731 hasRelatedWork W4232189731 @default.
- W4232189731 hasVolume "89" @default.
- W4232189731 isParatext "false" @default.
- W4232189731 isRetracted "false" @default.
- W4232189731 workType "article" @default.