FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232224755> ?p ?o ?g. }

• W4232224755 endingPage "1119" @default.
• W4232224755 startingPage "1109" @default.
• W4232224755 abstract "The role of podocytes in human crescentic glomerulonephritis (GN) has been underestimated. This may be due to the confounding fact that dysregulated podocytes are able to proliferate, lose their markers, and acquire new epitopes. Moreover, in experimental anti-glomerular basement membrane (GBM) crescentic GN, podocytes participate in the crescent formation. The aim of this study was to investigate the involvement of podocytes in human immune crescentic GN.Renal biopsies from 12 patients with anti-GBM disease and 14 with class IV lupus GN were studied by immunohistochemistry for the following markers: (1) synaptopodin, GLEPP1, podocalyxin, podocin, alpha-actinin-4, and vimentin for podocyte identification; (2) PCNA, Ki-67, and p57 for cell cycle assessment; (3) cytokeratins for identifying epithelial cells but not normal podocytes; (4) CD68 for tagging a macrophagic epitope; (5) alpha-smooth-muscle actin (alpha-SMA), a phenotypic marker of myofibroblasts.True (capsular) crescents lining Bowman's capsule and (tuft) pseudocrescents covering the glomerular tuft with a persistent patent urinary space were present in the 2 types of crescentic GN in similar percentages. Several features indicated that podocytes were involved in the formation of the both crescent types. Identifiable podocytes expressed proliferation markers. Podocyte cytoplasmic expansions and racket-like podocytes bridged between the tuft and Bowman's capsule. True and pseudocrescents contained labeled podocytes. In addition, podocytes located outside of the crescents had often lost their markers (dedifferentiation) and acquired new epitopes (cytokeratins and CD68).In human immune crescentic GN, podocytes undergo proliferation and dysregulation that are indicative of a podocytopathy. Podocytes contribute to crescent formation." @default.
• W4232224755 created "2022-05-12" @default.
• W4232224755 creator A5005266075 @default.
• W4232224755 creator A5028555797 @default.
• W4232224755 creator A5059751677 @default.
• W4232224755 creator A5066322468 @default.
• W4232224755 creator A5076713502 @default.
• W4232224755 creator A5089507696 @default.
• W4232224755 date "2005-09-01" @default.
• W4232224755 modified "2023-10-13" @default.
• W4232224755 title "Podocyte involvement in human immune crescentic glomerulonephritis" @default.
• W4232224755 cites W1969431544 @default.
• W4232224755 cites W1970591449 @default.
• W4232224755 cites W1982005004 @default.
• W4232224755 cites W1990413711 @default.
• W4232224755 cites W1992042148 @default.
• W4232224755 cites W1997512772 @default.
• W4232224755 cites W1998946957 @default.
• W4232224755 cites W2000637899 @default.
• W4232224755 cites W2003280511 @default.
• W4232224755 cites W2023208472 @default.
• W4232224755 cites W2033546600 @default.
• W4232224755 cites W2038261057 @default.
• W4232224755 cites W2040980668 @default.
• W4232224755 cites W2048894509 @default.
• W4232224755 cites W2050014106 @default.
• W4232224755 cites W2053910475 @default.
• W4232224755 cites W2081128090 @default.
• W4232224755 cites W2083455540 @default.
• W4232224755 cites W2085131644 @default.
• W4232224755 cites W2104790008 @default.
• W4232224755 cites W2106132002 @default.
• W4232224755 cites W2112873162 @default.
• W4232224755 cites W2138889351 @default.
• W4232224755 cites W2155183634 @default.
• W4232224755 cites W2156810483 @default.
• W4232224755 cites W2164780260 @default.
• W4232224755 cites W2166852366 @default.
• W4232224755 cites W2168287443 @default.
• W4232224755 cites W2169537329 @default.
• W4232224755 cites W2294457250 @default.
• W4232224755 doi "https://doi.org/10.1111/j.1523-1755.2005.00503.x" @default.
• W4232224755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16105041" @default.
• W4232224755 hasPublicationYear "2005" @default.
• W4232224755 type Work @default.
• W4232224755 citedByCount "41" @default.
• W4232224755 countsByYear W42322247552012 @default.
• W4232224755 countsByYear W42322247552013 @default.
• W4232224755 countsByYear W42322247552014 @default.
• W4232224755 countsByYear W42322247552015 @default.
• W4232224755 countsByYear W42322247552016 @default.
• W4232224755 countsByYear W42322247552017 @default.
• W4232224755 countsByYear W42322247552018 @default.
• W4232224755 countsByYear W42322247552019 @default.
• W4232224755 countsByYear W42322247552020 @default.
• W4232224755 countsByYear W42322247552021 @default.
• W4232224755 countsByYear W42322247552022 @default.
• W4232224755 countsByYear W42322247552023 @default.
• W4232224755 crossrefType "journal-article" @default.
• W4232224755 hasAuthorship W4232224755A5005266075 @default.
• W4232224755 hasAuthorship W4232224755A5028555797 @default.
• W4232224755 hasAuthorship W4232224755A5059751677 @default.
• W4232224755 hasAuthorship W4232224755A5066322468 @default.
• W4232224755 hasAuthorship W4232224755A5076713502 @default.
• W4232224755 hasAuthorship W4232224755A5089507696 @default.
• W4232224755 hasConcept C134018914 @default.
• W4232224755 hasConcept C142724271 @default.
• W4232224755 hasConcept C147447768 @default.
• W4232224755 hasConcept C159654299 @default.
• W4232224755 hasConcept C195616568 @default.
• W4232224755 hasConcept C203014093 @default.
• W4232224755 hasConcept C204232928 @default.
• W4232224755 hasConcept C2776855237 @default.
• W4232224755 hasConcept C2777146197 @default.
• W4232224755 hasConcept C2779134260 @default.
• W4232224755 hasConcept C2779561371 @default.
• W4232224755 hasConcept C2779912601 @default.
• W4232224755 hasConcept C2780091579 @default.
• W4232224755 hasConcept C2780368995 @default.
• W4232224755 hasConcept C2780819817 @default.
• W4232224755 hasConcept C2781156571 @default.
• W4232224755 hasConcept C2910727860 @default.
• W4232224755 hasConcept C71924100 @default.
• W4232224755 hasConcept C86803240 @default.
• W4232224755 hasConcept C95444343 @default.
• W4232224755 hasConceptScore W4232224755C134018914 @default.
• W4232224755 hasConceptScore W4232224755C142724271 @default.
• W4232224755 hasConceptScore W4232224755C147447768 @default.
• W4232224755 hasConceptScore W4232224755C159654299 @default.
• W4232224755 hasConceptScore W4232224755C195616568 @default.
• W4232224755 hasConceptScore W4232224755C203014093 @default.
• W4232224755 hasConceptScore W4232224755C204232928 @default.
• W4232224755 hasConceptScore W4232224755C2776855237 @default.
• W4232224755 hasConceptScore W4232224755C2777146197 @default.
• W4232224755 hasConceptScore W4232224755C2779134260 @default.
• W4232224755 hasConceptScore W4232224755C2779561371 @default.
• W4232224755 hasConceptScore W4232224755C2779912601 @default.
• W4232224755 hasConceptScore W4232224755C2780091579 @default.

• next