Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232268744> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4232268744 endingPage "452" @default.
- W4232268744 startingPage "450" @default.
- W4232268744 abstract "Double-expressor lymphoma (DEL) is a diffuse large B cell lymphoma that exhibits co-expression of MYC and BCL2 proteins by immunohistochemistry. Patients with double-expressor lymphoma have a poor prognosis after standard chemoimmunotherapy or after high-dose chemotherapy with autologous transplantation, but the prognostic impact of DEL after allogeneic hematopoietic cell transplantation has not been well characterized. We retrospectively analyzed 60 consecutive patients with de novo diffuse large B cell lymphoma or transformed follicular lymphoma who underwent allogeneic transplantation at our center and had available immunohistochemistry data. Thirty-seven patients (62%) had DEL. The 2-year progression-free and overall survival rates were lower in patients with DEL than in those without DEL (20% versus 78%; overall P <.001 and 46% versus 77%; overall P = .016, respectively). The cumulative incidence of disease progression at 2 years was higher in patients with DEL (60% versus 13%; overall P = .005). The cumulative incidence of nonrelapse mortality did not differ statistically in the 2 groups. Even in patients with DEL and chemosensitive disease at transplantation, the 2-year progression-free survival rate was only 27% due to early disease progression. Multivariate analysis showed associations between DEL and increased risks of progression-free survival events (hazard ratio [HR], 4.58; 95% confidence interval [CI], 2.07-10.2; P <.001), overall mortality (HR, 2.29; 95% CI, 1.03-5.09; P = .042) and disease progression (HR, 3.60; 95% CI, 1.38-9.44; P = .009). Patients with DEL had poor outcomes after allogeneic transplantation. Innovative strategies are needed to improve outcomes in this population." @default.
- W4232268744 created "2022-05-12" @default.
- W4232268744 creator A5074124634 @default.
- W4232268744 date "2002-07-01" @default.
- W4232268744 modified "2023-09-26" @default.
- W4232268744 title "Reviews" @default.
- W4232268744 doi "https://doi.org/10.1006/jhge.2002.0469" @default.
- W4232268744 hasPublicationYear "2002" @default.
- W4232268744 type Work @default.
- W4232268744 citedByCount "0" @default.
- W4232268744 crossrefType "journal-article" @default.
- W4232268744 hasAuthorship W4232268744A5074124634 @default.
- W4232268744 hasConcept C120665830 @default.
- W4232268744 hasConcept C121332964 @default.
- W4232268744 hasConcept C126322002 @default.
- W4232268744 hasConcept C141071460 @default.
- W4232268744 hasConcept C143998085 @default.
- W4232268744 hasConcept C207103383 @default.
- W4232268744 hasConcept C2776694085 @default.
- W4232268744 hasConcept C2777058707 @default.
- W4232268744 hasConcept C2777408962 @default.
- W4232268744 hasConcept C2779338263 @default.
- W4232268744 hasConcept C2780653079 @default.
- W4232268744 hasConcept C2780739268 @default.
- W4232268744 hasConcept C2780790343 @default.
- W4232268744 hasConcept C2911091166 @default.
- W4232268744 hasConcept C44249647 @default.
- W4232268744 hasConcept C61511704 @default.
- W4232268744 hasConcept C71924100 @default.
- W4232268744 hasConcept C88879693 @default.
- W4232268744 hasConcept C90924648 @default.
- W4232268744 hasConceptScore W4232268744C120665830 @default.
- W4232268744 hasConceptScore W4232268744C121332964 @default.
- W4232268744 hasConceptScore W4232268744C126322002 @default.
- W4232268744 hasConceptScore W4232268744C141071460 @default.
- W4232268744 hasConceptScore W4232268744C143998085 @default.
- W4232268744 hasConceptScore W4232268744C207103383 @default.
- W4232268744 hasConceptScore W4232268744C2776694085 @default.
- W4232268744 hasConceptScore W4232268744C2777058707 @default.
- W4232268744 hasConceptScore W4232268744C2777408962 @default.
- W4232268744 hasConceptScore W4232268744C2779338263 @default.
- W4232268744 hasConceptScore W4232268744C2780653079 @default.
- W4232268744 hasConceptScore W4232268744C2780739268 @default.
- W4232268744 hasConceptScore W4232268744C2780790343 @default.
- W4232268744 hasConceptScore W4232268744C2911091166 @default.
- W4232268744 hasConceptScore W4232268744C44249647 @default.
- W4232268744 hasConceptScore W4232268744C61511704 @default.
- W4232268744 hasConceptScore W4232268744C71924100 @default.
- W4232268744 hasConceptScore W4232268744C88879693 @default.
- W4232268744 hasConceptScore W4232268744C90924648 @default.
- W4232268744 hasIssue "3" @default.
- W4232268744 hasLocation W42322687441 @default.
- W4232268744 hasOpenAccess W4232268744 @default.
- W4232268744 hasPrimaryLocation W42322687441 @default.
- W4232268744 hasRelatedWork W2004368639 @default.
- W4232268744 hasRelatedWork W2044056025 @default.
- W4232268744 hasRelatedWork W2102241654 @default.
- W4232268744 hasRelatedWork W2114624491 @default.
- W4232268744 hasRelatedWork W2194631636 @default.
- W4232268744 hasRelatedWork W2205883634 @default.
- W4232268744 hasRelatedWork W2360260519 @default.
- W4232268744 hasRelatedWork W2464045689 @default.
- W4232268744 hasRelatedWork W2762919771 @default.
- W4232268744 hasRelatedWork W4239668963 @default.
- W4232268744 hasVolume "28" @default.
- W4232268744 isParatext "false" @default.
- W4232268744 isRetracted "false" @default.
- W4232268744 workType "article" @default.