Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232273141> ?p ?o ?g. }
- W4232273141 endingPage "300" @default.
- W4232273141 startingPage "291" @default.
- W4232273141 abstract "Why do patients with cholestasis have pruritus? The pruritus may be due to the accumulation of pruritogens in body compartments; it is proposed that this type of pruritus is mediated, at least in part, by increased opioidergic tone, as the pruritus is decreased by opiate antagonists, a therapeutic option. Serotoninergic, dopaminergic, and substance P mediated neurotransmission may also contribute to the mediation of the pruritus of cholestasis. A role of lipophosphatidic acid and the enzyme that regulates its generation, autotaxin, is being proposed. Treatment with the antibiotic rifampicin, and with serotonin-reuptake inhibitor sertraline is also a therapeutic alternative. The role of recently identified channels and receptors in the mediation of scratching in animals including gastrin releasing peptide receptor, mu opioid receptor 1 D isoform, and transient receptor potential vanilloid receptor-1 merit investigation in the transmission of the itch sensation, including that associated with cholestasis, in human beings." @default.
- W4232273141 created "2022-05-12" @default.
- W4232273141 creator A5055473574 @default.
- W4232273141 date "2015-01-30" @default.
- W4232273141 modified "2023-10-01" @default.
- W4232273141 title "Pruritus" @default.
- W4232273141 cites W107290262 @default.
- W4232273141 cites W1219313770 @default.
- W4232273141 cites W1495781935 @default.
- W4232273141 cites W1568521174 @default.
- W4232273141 cites W1571099695 @default.
- W4232273141 cites W1933695927 @default.
- W4232273141 cites W1964444312 @default.
- W4232273141 cites W1981048344 @default.
- W4232273141 cites W1983148582 @default.
- W4232273141 cites W1991950974 @default.
- W4232273141 cites W1998622278 @default.
- W4232273141 cites W2005678638 @default.
- W4232273141 cites W2008756039 @default.
- W4232273141 cites W2012543042 @default.
- W4232273141 cites W2012917581 @default.
- W4232273141 cites W2013241580 @default.
- W4232273141 cites W2027084144 @default.
- W4232273141 cites W2028210202 @default.
- W4232273141 cites W2030957324 @default.
- W4232273141 cites W2031005702 @default.
- W4232273141 cites W2031100869 @default.
- W4232273141 cites W2032058959 @default.
- W4232273141 cites W2033272737 @default.
- W4232273141 cites W2043872663 @default.
- W4232273141 cites W2046010012 @default.
- W4232273141 cites W2046254173 @default.
- W4232273141 cites W2047004512 @default.
- W4232273141 cites W2054124635 @default.
- W4232273141 cites W2055077741 @default.
- W4232273141 cites W2058312660 @default.
- W4232273141 cites W2059876429 @default.
- W4232273141 cites W2061580732 @default.
- W4232273141 cites W2065757847 @default.
- W4232273141 cites W2068736424 @default.
- W4232273141 cites W2075054530 @default.
- W4232273141 cites W2075314339 @default.
- W4232273141 cites W2079146831 @default.
- W4232273141 cites W2080561720 @default.
- W4232273141 cites W2084074511 @default.
- W4232273141 cites W2088033893 @default.
- W4232273141 cites W2088483147 @default.
- W4232273141 cites W2090927292 @default.
- W4232273141 cites W2090988554 @default.
- W4232273141 cites W2108087274 @default.
- W4232273141 cites W2108258874 @default.
- W4232273141 cites W2120577168 @default.
- W4232273141 cites W2127182991 @default.
- W4232273141 cites W2136105869 @default.
- W4232273141 cites W2139861148 @default.
- W4232273141 cites W2140123841 @default.
- W4232273141 cites W2144300067 @default.
- W4232273141 cites W2144641720 @default.
- W4232273141 cites W2145593979 @default.
- W4232273141 cites W2154052609 @default.
- W4232273141 cites W2168681401 @default.
- W4232273141 cites W2169053291 @default.
- W4232273141 cites W2395466827 @default.
- W4232273141 cites W4245137094 @default.
- W4232273141 doi "https://doi.org/10.1002/9781118412640.ch26" @default.
- W4232273141 hasPublicationYear "2015" @default.
- W4232273141 type Work @default.
- W4232273141 citedByCount "0" @default.
- W4232273141 crossrefType "other" @default.
- W4232273141 hasAuthorship W4232273141A5055473574 @default.
- W4232273141 hasConcept C126322002 @default.
- W4232273141 hasConcept C170493617 @default.
- W4232273141 hasConcept C185592680 @default.
- W4232273141 hasConcept C2775864247 @default.
- W4232273141 hasConcept C2778750930 @default.
- W4232273141 hasConcept C2779004600 @default.
- W4232273141 hasConcept C2781063702 @default.
- W4232273141 hasConcept C37000724 @default.
- W4232273141 hasConcept C71924100 @default.
- W4232273141 hasConcept C98274493 @default.
- W4232273141 hasConceptScore W4232273141C126322002 @default.
- W4232273141 hasConceptScore W4232273141C170493617 @default.
- W4232273141 hasConceptScore W4232273141C185592680 @default.
- W4232273141 hasConceptScore W4232273141C2775864247 @default.
- W4232273141 hasConceptScore W4232273141C2778750930 @default.
- W4232273141 hasConceptScore W4232273141C2779004600 @default.
- W4232273141 hasConceptScore W4232273141C2781063702 @default.
- W4232273141 hasConceptScore W4232273141C37000724 @default.
- W4232273141 hasConceptScore W4232273141C71924100 @default.
- W4232273141 hasConceptScore W4232273141C98274493 @default.
- W4232273141 hasLocation W42322731411 @default.
- W4232273141 hasOpenAccess W4232273141 @default.
- W4232273141 hasPrimaryLocation W42322731411 @default.
- W4232273141 hasRelatedWork W1984841954 @default.
- W4232273141 hasRelatedWork W2019365375 @default.
- W4232273141 hasRelatedWork W2050824222 @default.
- W4232273141 hasRelatedWork W2075568459 @default.
- W4232273141 hasRelatedWork W2087454008 @default.