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- W4232279317 endingPage "283" @default.
- W4232279317 startingPage "272" @default.
- W4232279317 abstract "The most common administration route for pharmaceuticals is the oral one. A drug orally administered has to undergo several processes in order to carry out its therapeutic potential. The pharmaceutical has to dissolve and to release the API (Active Pharmaceutical Ingredient) in the desired location along the GI (Gastro Intestinal) tract, to pass through the intestinal wall, to overcome the liver (first-pass metabolism), and finally to reach the plasma, where it has to be stable during its travel toward the target organ/tissue. The key roles in this complex framework are played by the design (such as matrices, reservoirs, enteric systems) and the testing of the pharmaceuticals. This review is focused on the state of the art in the pharmaceutical testing methods, carried out by the simulation of what happens once the pharmaceutical has been administered, investigating the in vitro approach. In the first section, the generalities of the dissolution and the ADME (Adsorption, Distribution, Metabolism and Excretion) phenomena are investigated. In the second section, the in vitro apparatuses are described, with a special focus on the role of food in their design and behavior. Some case histories of application for each approach are also discussed." @default.
- W4232279317 created "2022-05-12" @default.
- W4232279317 creator A5025895994 @default.
- W4232279317 creator A5026664152 @default.
- W4232279317 creator A5031149340 @default.
- W4232279317 creator A5031452038 @default.
- W4232279317 creator A5051902697 @default.
- W4232279317 creator A5061941133 @default.
- W4232279317 date "2016-10-01" @default.
- W4232279317 modified "2023-10-18" @default.
- W4232279317 title "Gastrointestinal behavior and ADME phenomena: I. In vitro simulation" @default.
- W4232279317 cites W1425121398 @default.
- W4232279317 cites W1498305210 @default.
- W4232279317 cites W1517895213 @default.
- W4232279317 cites W1522767714 @default.
- W4232279317 cites W1527851449 @default.
- W4232279317 cites W1551059844 @default.
- W4232279317 cites W1560319813 @default.
- W4232279317 cites W1937613257 @default.
- W4232279317 cites W1966830855 @default.
- W4232279317 cites W1967486087 @default.
- W4232279317 cites W1968644819 @default.
- W4232279317 cites W1971386461 @default.
- W4232279317 cites W1973036292 @default.
- W4232279317 cites W1973092320 @default.
- W4232279317 cites W1974774407 @default.
- W4232279317 cites W1975334989 @default.
- W4232279317 cites W1975443244 @default.
- W4232279317 cites W1979136851 @default.
- W4232279317 cites W1979475426 @default.
- W4232279317 cites W1980146727 @default.
- W4232279317 cites W1982071369 @default.
- W4232279317 cites W1982157333 @default.
- W4232279317 cites W1982244720 @default.
- W4232279317 cites W1985356444 @default.
- W4232279317 cites W1986440028 @default.
- W4232279317 cites W1987028317 @default.
- W4232279317 cites W1988137261 @default.
- W4232279317 cites W1988414197 @default.
- W4232279317 cites W1990129807 @default.
- W4232279317 cites W1993834909 @default.
- W4232279317 cites W1996280064 @default.
- W4232279317 cites W2001153375 @default.
- W4232279317 cites W2004623177 @default.
- W4232279317 cites W2007915887 @default.
- W4232279317 cites W2014307488 @default.
- W4232279317 cites W2017336071 @default.
- W4232279317 cites W2022440335 @default.
- W4232279317 cites W2026657095 @default.
- W4232279317 cites W2030247333 @default.
- W4232279317 cites W2032865438 @default.
- W4232279317 cites W2034613829 @default.
- W4232279317 cites W2034790916 @default.
- W4232279317 cites W2035372950 @default.
- W4232279317 cites W2042688551 @default.
- W4232279317 cites W2046788693 @default.
- W4232279317 cites W2046827775 @default.
- W4232279317 cites W2050328092 @default.
- W4232279317 cites W2051236177 @default.
- W4232279317 cites W2051267989 @default.
- W4232279317 cites W2052389363 @default.
- W4232279317 cites W2052427027 @default.
- W4232279317 cites W2054884344 @default.
- W4232279317 cites W2057160608 @default.
- W4232279317 cites W2057212965 @default.
- W4232279317 cites W2058604839 @default.
- W4232279317 cites W2059373792 @default.
- W4232279317 cites W2059612467 @default.
- W4232279317 cites W2061742628 @default.
- W4232279317 cites W2063317482 @default.
- W4232279317 cites W2065990421 @default.
- W4232279317 cites W2069034703 @default.
- W4232279317 cites W2073101936 @default.
- W4232279317 cites W2073430961 @default.
- W4232279317 cites W2076703575 @default.
- W4232279317 cites W2078694607 @default.
- W4232279317 cites W2085680572 @default.
- W4232279317 cites W2088515694 @default.
- W4232279317 cites W2089852255 @default.
- W4232279317 cites W2090901001 @default.
- W4232279317 cites W2093234705 @default.
- W4232279317 cites W2097519121 @default.
- W4232279317 cites W2104438858 @default.
- W4232279317 cites W2106341025 @default.
- W4232279317 cites W2109755334 @default.
- W4232279317 cites W2111431523 @default.
- W4232279317 cites W2111458473 @default.
- W4232279317 cites W2111960495 @default.
- W4232279317 cites W2122238291 @default.
- W4232279317 cites W2154145626 @default.
- W4232279317 cites W2168400328 @default.
- W4232279317 cites W2171262782 @default.
- W4232279317 cites W2313111252 @default.
- W4232279317 cites W2313581353 @default.
- W4232279317 cites W2319334300 @default.
- W4232279317 cites W2321337839 @default.
- W4232279317 cites W2321728637 @default.
- W4232279317 cites W2323342355 @default.