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• W4232325535 abstract "Abstract Background: Increasing evidence suggests that antibiotic administration causes gut injury, nutrient digestion, immune regulation, and colonization resistance against pathogens due to the disruption of gut microbiota. However, the time-course effects of therapeutic antibiotics on alterations of gut microbes and short-chain fatty acid in young swine are still unknown. In this study, twenty piglets were assigned into two groups and fed commercial diets with or without lincomycin in the first week for a 28-day trial period. Results: Data showed that one-week lincomycin exposure did reduce the body weight on day 14 ( p = 0.0450) and 28 ( p = 0.0362). The alpha-diversity notably reduced after one-week lincomycin treatment, then gradually raised and reached the control group level in the second week on cessation of lincomycin exposure, indicated by the variation of Sobs, Chao, Shannon, and ACE index ( p < 0.05). Beta-diversity analysis revealed that the distinct microbial cluster existed persistently for the whole trial period between two groups ( p < 0.001). The relative abundance of most microbes including fiber-degrading (e.g., Agathobacter , Coprococcus , etc. ), beneficial (e.g., Lactobacillus , Mitsuokella , etc. ), or pathogenic bacteria (e.g., Terrisporobacter , Lachnoclostridium , etc. ) decreased and the concentration of short-chain fatty acids also diminished in the feces of one-week lincomycin-administrated young swine (LDA score > 3). After the lincomycin administration stopped, the state of gut dysbiosis gradually recovered and formed new gut-microbe homeostasis distinct from microbial homeostasis of young pigs unexposed to lincomycin. The increased presence of potential pathogens, such as Terrisporobacter , Negativibacillus , Escherichia-Shigella , etc. and decreased beneficial bacteria such as Lactobacillus , Agathobacter were observed in new homeostasis reshaped by short-lincomycin administration (LDA score > 3 or p < 0.05), adversely affecting gut development and health of young pigs. Conclusion: Collectively, these results suggested that severe disruption of the commensal microbiota occurred after short-term lincomycin exposure or termination of lincomycin exposure in young swine. Our study depicts the change rule of gut microbiota in young animals under the condition of short-term lincomycin treatment, providing basic data for evaluating the harmful impact on gut microbe of young animals." @default.
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• W4232325535 date "2021-08-17" @default.
• W4232325535 modified "2023-09-30" @default.
• W4232325535 title "Time-course Alterations of Gut Microbiota and Short-chain Fatty Acids After Short-term Lincomycin Exposure in Young Swine" @default.
• W4232325535 doi "https://doi.org/10.21203/rs.3.rs-786748/v1" @default.
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