Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232371050> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4232371050 endingPage "1186" @default.
- W4232371050 startingPage "1185" @default.
- W4232371050 abstract "SummaryNovelty: Novel 3-benzoyl indol-1-yl derivatives are claimed together with their methods of preparation. They are said to be steriodal 5α-reductase inhibitors and are potentially useful for the treatment of acne vulgaris, alopecia, seborrhoea, female hirsutism, benign prostate hypertrophy, male pattern baldness and human prostate adenocarcinoma.Biology: Testosterone 5α-reductase inhibitory activity was assessed using ventral prostate tissue from male rats and tritiated testosterone. The inhibitory effect of the test compounds on the formulation of 5α-dihydro-testosterone was determined using thin layer chromatography. The most active compounds caused 50% inhibition in the range 1–5 nM.Chemistry: The syntheses of forty-three compounds are described by standard methods and characterized by nmr and mass spectrometry. Four compounds are specifically claimed including (S)-4-(3-[4-(1-[4-(2-methylpropyl)phenyl]ethoxy)-benzoyl]indol-1-yl)butanoic acid." @default.
- W4232371050 created "2022-05-12" @default.
- W4232371050 date "1993-08-01" @default.
- W4232371050 modified "2023-09-24" @default.
- W4232371050 title "Patent Evaluation: Indolyl 5α-reductase inhibitors" @default.
- W4232371050 cites W107210901 @default.
- W4232371050 cites W1997479221 @default.
- W4232371050 cites W2000173210 @default.
- W4232371050 cites W2029706340 @default.
- W4232371050 cites W2037740608 @default.
- W4232371050 cites W2404510827 @default.
- W4232371050 doi "https://doi.org/10.1517/13543776.3.8.1185" @default.
- W4232371050 hasPublicationYear "1993" @default.
- W4232371050 type Work @default.
- W4232371050 citedByCount "0" @default.
- W4232371050 crossrefType "journal-article" @default.
- W4232371050 hasConcept C121608353 @default.
- W4232371050 hasConcept C126322002 @default.
- W4232371050 hasConcept C134651460 @default.
- W4232371050 hasConcept C16005928 @default.
- W4232371050 hasConcept C181199279 @default.
- W4232371050 hasConcept C185592680 @default.
- W4232371050 hasConcept C2775874879 @default.
- W4232371050 hasConcept C2776235491 @default.
- W4232371050 hasConcept C2776371013 @default.
- W4232371050 hasConcept C2777391703 @default.
- W4232371050 hasConcept C2777673923 @default.
- W4232371050 hasConcept C2779279991 @default.
- W4232371050 hasConcept C2779306644 @default.
- W4232371050 hasConcept C2910366748 @default.
- W4232371050 hasConcept C3018442814 @default.
- W4232371050 hasConcept C55493867 @default.
- W4232371050 hasConcept C71924100 @default.
- W4232371050 hasConcept C98274493 @default.
- W4232371050 hasConceptScore W4232371050C121608353 @default.
- W4232371050 hasConceptScore W4232371050C126322002 @default.
- W4232371050 hasConceptScore W4232371050C134651460 @default.
- W4232371050 hasConceptScore W4232371050C16005928 @default.
- W4232371050 hasConceptScore W4232371050C181199279 @default.
- W4232371050 hasConceptScore W4232371050C185592680 @default.
- W4232371050 hasConceptScore W4232371050C2775874879 @default.
- W4232371050 hasConceptScore W4232371050C2776235491 @default.
- W4232371050 hasConceptScore W4232371050C2776371013 @default.
- W4232371050 hasConceptScore W4232371050C2777391703 @default.
- W4232371050 hasConceptScore W4232371050C2777673923 @default.
- W4232371050 hasConceptScore W4232371050C2779279991 @default.
- W4232371050 hasConceptScore W4232371050C2779306644 @default.
- W4232371050 hasConceptScore W4232371050C2910366748 @default.
- W4232371050 hasConceptScore W4232371050C3018442814 @default.
- W4232371050 hasConceptScore W4232371050C55493867 @default.
- W4232371050 hasConceptScore W4232371050C71924100 @default.
- W4232371050 hasConceptScore W4232371050C98274493 @default.
- W4232371050 hasIssue "8" @default.
- W4232371050 hasLocation W42323710501 @default.
- W4232371050 hasOpenAccess W4232371050 @default.
- W4232371050 hasPrimaryLocation W42323710501 @default.
- W4232371050 hasRelatedWork W1999962914 @default.
- W4232371050 hasRelatedWork W2045360813 @default.
- W4232371050 hasRelatedWork W2064185841 @default.
- W4232371050 hasRelatedWork W2066737997 @default.
- W4232371050 hasRelatedWork W2069083739 @default.
- W4232371050 hasRelatedWork W2079213361 @default.
- W4232371050 hasRelatedWork W2108511792 @default.
- W4232371050 hasRelatedWork W2404510827 @default.
- W4232371050 hasRelatedWork W3213981265 @default.
- W4232371050 hasRelatedWork W60006070 @default.
- W4232371050 hasVolume "3" @default.
- W4232371050 isParatext "false" @default.
- W4232371050 isRetracted "false" @default.
- W4232371050 workType "article" @default.