FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232425394> ?p ?o ?g. }

• W4232425394 endingPage "e101" @default.
• W4232425394 startingPage "e101" @default.
• W4232425394 abstract "Restless legs syndrome (RLS) is a frequent pathology, yet underrated and underestimated, affecting inasmuch as 5–10% of the population as a whole. However the pathophysiology has not been completely understood. The dopaminergic system has certainly a primary role, and some studies have highlighted a condition of spinal hyper-excitability. The aim of our study is to explore this hypothesis throughout the electrophysiological evaluation of the spinal and peripheral nervous system in primitives RLS patients. Among the patients affected by primitive RLS admitted to our Sleep Centerlab, we selected 15 women, and compared them with 17 control subjects of the same sex and age. All subjects had undergone ENG evaluation to exclude any secondary causes of lower limb paresthesia and to evaluate spinal excitability. According to a previous study, we considered two parameters which can be easily extracted from the routine tests normally carried out in the neurophysiopathology labs, the duration of F waves (FWD) of the Internal Popliteal (IPN) and ulnar nerves, and the relationship between FWD and the duration of the corresponding CMAP (CMAPD). None of the subjects (RLS and controls) included in our study presented alterations in the nerve conduction velocity. Compared to the control group, significantly higher values were found in the RLS patients for the FWD/CMAPD ratio average (p < 0.001 test Mann–Whitney) and for the FWD average for both nerves ulnar (p < 0.05 unpaired t-test) and IPN (p < 0.01 unpaired t-test). The results of our study confirm the absence of peripheral involvement in primitive RLS, while they indicate a spinal motorneuronal hyper-excitability, which seems widespread, as both IPN and ulnar nerve stimulation indicators are altered. Such condition could be due mainly to an alteration of the modulation in the interneuronal system. Presently, RLS diagnosis is based exclusively on clinical criteria. The FWD/CMAPD ratio can help to shed light on the pathogenesis of RLS, and can be used as an instrumental diagnostic indicator, easily obtainable and useful especially in cases of lower leg discomfort at night of unclear interpretation. The authors would like to thank Prof. F. Marrosu and Dr. M. Fraschini, University of Cagliari, Italy, and Prof. L. Parrino, University of Parma, Italy, for their important contribution." @default.
• W4232425394 created "2022-05-12" @default.
• W4232425394 creator A5001827320 @default.
• W4232425394 creator A5006151480 @default.
• W4232425394 creator A5055747230 @default.
• W4232425394 creator A5059156656 @default.
• W4232425394 creator A5062182198 @default.
• W4232425394 creator A5067400480 @default.
• W4232425394 date "2013-12-01" @default.
• W4232425394 modified "2023-09-26" @default.
• W4232425394 title "Neurophysiological evaluation of spinal excitability in patients affected by primitive restless legs syndrome" @default.
• W4232425394 doi "https://doi.org/10.1016/j.sleep.2013.11.217" @default.
• W4232425394 hasPublicationYear "2013" @default.
• W4232425394 type Work @default.
• W4232425394 citedByCount "0" @default.
• W4232425394 crossrefType "journal-article" @default.
• W4232425394 hasAuthorship W4232425394A5001827320 @default.
• W4232425394 hasAuthorship W4232425394A5006151480 @default.
• W4232425394 hasAuthorship W4232425394A5055747230 @default.
• W4232425394 hasAuthorship W4232425394A5059156656 @default.
• W4232425394 hasAuthorship W4232425394A5062182198 @default.
• W4232425394 hasAuthorship W4232425394A5067400480 @default.
• W4232425394 hasConcept C10162356 @default.
• W4232425394 hasConcept C105702510 @default.
• W4232425394 hasConcept C118552586 @default.
• W4232425394 hasConcept C126322002 @default.
• W4232425394 hasConcept C137183658 @default.
• W4232425394 hasConcept C152478114 @default.
• W4232425394 hasConcept C16568411 @default.
• W4232425394 hasConcept C179253579 @default.
• W4232425394 hasConcept C2776750294 @default.
• W4232425394 hasConcept C2778931672 @default.
• W4232425394 hasConcept C2781184374 @default.
• W4232425394 hasConcept C2908647359 @default.
• W4232425394 hasConcept C46762472 @default.
• W4232425394 hasConcept C513476851 @default.
• W4232425394 hasConcept C71924100 @default.
• W4232425394 hasConcept C99454951 @default.
• W4232425394 hasConceptScore W4232425394C10162356 @default.
• W4232425394 hasConceptScore W4232425394C105702510 @default.
• W4232425394 hasConceptScore W4232425394C118552586 @default.
• W4232425394 hasConceptScore W4232425394C126322002 @default.
• W4232425394 hasConceptScore W4232425394C137183658 @default.
• W4232425394 hasConceptScore W4232425394C152478114 @default.
• W4232425394 hasConceptScore W4232425394C16568411 @default.
• W4232425394 hasConceptScore W4232425394C179253579 @default.
• W4232425394 hasConceptScore W4232425394C2776750294 @default.
• W4232425394 hasConceptScore W4232425394C2778931672 @default.
• W4232425394 hasConceptScore W4232425394C2781184374 @default.
• W4232425394 hasConceptScore W4232425394C2908647359 @default.
• W4232425394 hasConceptScore W4232425394C46762472 @default.
• W4232425394 hasConceptScore W4232425394C513476851 @default.
• W4232425394 hasConceptScore W4232425394C71924100 @default.
• W4232425394 hasConceptScore W4232425394C99454951 @default.
• W4232425394 hasLocation W42324253941 @default.
• W4232425394 hasOpenAccess W4232425394 @default.
• W4232425394 hasPrimaryLocation W42324253941 @default.
• W4232425394 hasRelatedWork W1989254190 @default.
• W4232425394 hasRelatedWork W2014694842 @default.
• W4232425394 hasRelatedWork W2030700067 @default.
• W4232425394 hasRelatedWork W2072854917 @default.
• W4232425394 hasRelatedWork W2119970097 @default.
• W4232425394 hasRelatedWork W2122317547 @default.
• W4232425394 hasRelatedWork W2123128199 @default.
• W4232425394 hasRelatedWork W2418800198 @default.
• W4232425394 hasRelatedWork W2495935124 @default.
• W4232425394 hasRelatedWork W2979832716 @default.
• W4232425394 hasVolume "14" @default.
• W4232425394 isParatext "false" @default.
• W4232425394 isRetracted "false" @default.
• W4232425394 workType "article" @default.