FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232510768> ?p ?o ?g. }

• W4232510768 endingPage "e1229" @default.
• W4232510768 startingPage "e1229" @default.
• W4232510768 abstract "Background: Acute lymphoblastic leukemia (ALL) is a highly prevalent pediatric cancer accounting for approximately 78% of leukemia cases in patients younger than 15 years old. Different studies have demonstrated that B-cell translocation gene 3 (BTG3) plays a suppressive role in the progress of different cancers. Genistein is considered a natural and biocompatible compound and a new anti-cancer agent. In this study, we evaluate the effect of genistein on BTG3 expression and proliferation of ALL cancer cells. Materials and Methods: ALL cell lines (MOLT4, MOLT17, and JURKAT) were cultured in standard conditions. Cytotoxicity of genistein was detected using MTT assay. The cells were treated with different concentrations of genistein (10, 25, 40, and 55μM) for 24, 48, and 72 hours, and then cell viability and growth rate were measured. The quantitative real-time polymerase chain reaction was applied to investigate the effect of genistein on BTG3 expression. Results: The percentage of vital cells treated with genistein significantly decreased compared to the non-treated cells, showed an inverse relationship with an increasing genistein concentration. The present study suggests a dose of 40μM for genistein as a potent anticancer effect. Genistein could elevate BTG3 for 1.7 folds in MOLT4 and JURKAT and 2.7 folds in MOLT17 cell lines at transcription level conveged with 60 to 90% reduction in the proliferation rate of cancer cells. Conclusion: Up-regulation of BTG3 as a tumor suppressor gene can be induced by genistein. It seems that BTG3 reactivation can be introduced as another mechanism of anti-proliferative effect of genistein and could be considered as a retardant agent candidate against hematopoietic malignancy.[GMJ.2019;8:e1229]" @default.
• W4232510768 created "2022-05-12" @default.
• W4232510768 creator A5003419544 @default.
• W4232510768 creator A5011901753 @default.
• W4232510768 creator A5081591137 @default.
• W4232510768 creator A5089038665 @default.
• W4232510768 date "2019-03-26" @default.
• W4232510768 modified "2023-10-14" @default.
• W4232510768 title "Restraining the Proliferation of Acute Lymphoblastic Leukemia Cells by Genistein through Up-regulation of B-cell Translocation Gene-3 at Transcription Level" @default.
• W4232510768 cites W1232084907 @default.
• W4232510768 cites W1556996865 @default.
• W4232510768 cites W1569839307 @default.
• W4232510768 cites W1725513595 @default.
• W4232510768 cites W1789961596 @default.
• W4232510768 cites W1966912177 @default.
• W4232510768 cites W1985219239 @default.
• W4232510768 cites W1987446594 @default.
• W4232510768 cites W1996432277 @default.
• W4232510768 cites W2006608621 @default.
• W4232510768 cites W2007240193 @default.
• W4232510768 cites W2009526752 @default.
• W4232510768 cites W2014676294 @default.
• W4232510768 cites W2020674120 @default.
• W4232510768 cites W2021327963 @default.
• W4232510768 cites W2025896412 @default.
• W4232510768 cites W2028594253 @default.
• W4232510768 cites W2040347132 @default.
• W4232510768 cites W2041322119 @default.
• W4232510768 cites W2041679683 @default.
• W4232510768 cites W2046687399 @default.
• W4232510768 cites W2049009894 @default.
• W4232510768 cites W2050779480 @default.
• W4232510768 cites W2054736504 @default.
• W4232510768 cites W2060623598 @default.
• W4232510768 cites W2068435470 @default.
• W4232510768 cites W2068755589 @default.
• W4232510768 cites W2080261166 @default.
• W4232510768 cites W2080537230 @default.
• W4232510768 cites W2087198441 @default.
• W4232510768 cites W2089525043 @default.
• W4232510768 cites W2090314062 @default.
• W4232510768 cites W2097642356 @default.
• W4232510768 cites W2101546285 @default.
• W4232510768 cites W2105326401 @default.
• W4232510768 cites W2106877039 @default.
• W4232510768 cites W2110712343 @default.
• W4232510768 cites W2111359229 @default.
• W4232510768 cites W2111541751 @default.
• W4232510768 cites W2114340167 @default.
• W4232510768 cites W2117402371 @default.
• W4232510768 cites W2135815225 @default.
• W4232510768 cites W2136636869 @default.
• W4232510768 cites W2149717303 @default.
• W4232510768 cites W2156559492 @default.
• W4232510768 cites W2157826022 @default.
• W4232510768 cites W2163840069 @default.
• W4232510768 cites W2177573341 @default.
• W4232510768 cites W2318098003 @default.
• W4232510768 cites W2342262712 @default.
• W4232510768 cites W2911807115 @default.
• W4232510768 cites W4232414730 @default.
• W4232510768 doi "https://doi.org/10.31661/gmj.v8i0.1229" @default.
• W4232510768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34466474" @default.
• W4232510768 hasPublicationYear "2019" @default.
• W4232510768 type Work @default.
• W4232510768 citedByCount "2" @default.
• W4232510768 countsByYear W42325107682020 @default.
• W4232510768 countsByYear W42325107682022 @default.
• W4232510768 crossrefType "journal-article" @default.
• W4232510768 hasAuthorship W4232510768A5003419544 @default.
• W4232510768 hasAuthorship W4232510768A5011901753 @default.
• W4232510768 hasAuthorship W4232510768A5081591137 @default.
• W4232510768 hasAuthorship W4232510768A5089038665 @default.
• W4232510768 hasBestOaLocation W42325107681 @default.
• W4232510768 hasConcept C109316439 @default.
• W4232510768 hasConcept C126322002 @default.
• W4232510768 hasConcept C1491633281 @default.
• W4232510768 hasConcept C179464577 @default.
• W4232510768 hasConcept C202751555 @default.
• W4232510768 hasConcept C203014093 @default.
• W4232510768 hasConcept C2776090121 @default.
• W4232510768 hasConcept C2776913467 @default.
• W4232510768 hasConcept C2778298627 @default.
• W4232510768 hasConcept C2778461978 @default.
• W4232510768 hasConcept C502942594 @default.
• W4232510768 hasConcept C55493867 @default.
• W4232510768 hasConcept C62112901 @default.
• W4232510768 hasConcept C71924100 @default.
• W4232510768 hasConcept C86803240 @default.
• W4232510768 hasConcept C8891405 @default.
• W4232510768 hasConceptScore W4232510768C109316439 @default.
• W4232510768 hasConceptScore W4232510768C126322002 @default.
• W4232510768 hasConceptScore W4232510768C1491633281 @default.
• W4232510768 hasConceptScore W4232510768C179464577 @default.
• W4232510768 hasConceptScore W4232510768C202751555 @default.
• W4232510768 hasConceptScore W4232510768C203014093 @default.
• W4232510768 hasConceptScore W4232510768C2776090121 @default.
• W4232510768 hasConceptScore W4232510768C2776913467 @default.

• next