Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232557712> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4232557712 abstract "Abstract Objective: Nigeria bears 25% of global malaria burden despite concerted efforts towards its control and elimination. The emergence of drug resistance to first line drugs, artemisinin combination therapies (ACTs), indicates an urgent need for continuous molecular surveillance of drug resistance especially in high burden countries where drug interventions are heavily relied on. This study describes mutations in Plasmodium falciparum genes associated with drug resistance in malaria; Pfk1 3, Pfmdr1 , PfATPase6 and Pfcrt in isolates obtained from 83 symptomatic malaria patients between 1-61 years old from Lagos, a Mega city in South-west Nigeria. Results: Two Pfmdr 1, N86 and Y184 variants were present at a prevalence of 56% and 13.25% of isolates respectively. There was one synonymous (S679S) and two non-synonymous (M699V, S769M) mutations in the Pfatp6 gene, while Pfcrt genotype (CVIET), had a prevalence of 45%. The Pfk13 C580Y mutant allele was suspected by allelic discrimination in two samples with mixed genotypes. Our findings calls for robust molecular surveillance of antimalarial drug resistance markers in west Africa especially with increased use of antimalarial drugs as prophylaxis for covid-19." @default.
- W4232557712 created "2022-05-12" @default.
- W4232557712 creator A5001788797 @default.
- W4232557712 creator A5002409925 @default.
- W4232557712 creator A5008280787 @default.
- W4232557712 creator A5009624469 @default.
- W4232557712 creator A5049561197 @default.
- W4232557712 creator A5090544460 @default.
- W4232557712 date "2020-08-21" @default.
- W4232557712 modified "2023-10-17" @default.
- W4232557712 title "Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria" @default.
- W4232557712 doi "https://doi.org/10.21203/rs.3.rs-35555/v2" @default.
- W4232557712 hasPublicationYear "2020" @default.
- W4232557712 type Work @default.
- W4232557712 citedByCount "0" @default.
- W4232557712 crossrefType "posted-content" @default.
- W4232557712 hasAuthorship W4232557712A5001788797 @default.
- W4232557712 hasAuthorship W4232557712A5002409925 @default.
- W4232557712 hasAuthorship W4232557712A5008280787 @default.
- W4232557712 hasAuthorship W4232557712A5009624469 @default.
- W4232557712 hasAuthorship W4232557712A5049561197 @default.
- W4232557712 hasAuthorship W4232557712A5090544460 @default.
- W4232557712 hasBestOaLocation W42325577121 @default.
- W4232557712 hasConcept C104317684 @default.
- W4232557712 hasConcept C114851261 @default.
- W4232557712 hasConcept C135763542 @default.
- W4232557712 hasConcept C159047783 @default.
- W4232557712 hasConcept C203014093 @default.
- W4232557712 hasConcept C2776120307 @default.
- W4232557712 hasConcept C2778048844 @default.
- W4232557712 hasConcept C2778371730 @default.
- W4232557712 hasConcept C2780035454 @default.
- W4232557712 hasConcept C54355233 @default.
- W4232557712 hasConcept C71924100 @default.
- W4232557712 hasConcept C86803240 @default.
- W4232557712 hasConcept C98274493 @default.
- W4232557712 hasConceptScore W4232557712C104317684 @default.
- W4232557712 hasConceptScore W4232557712C114851261 @default.
- W4232557712 hasConceptScore W4232557712C135763542 @default.
- W4232557712 hasConceptScore W4232557712C159047783 @default.
- W4232557712 hasConceptScore W4232557712C203014093 @default.
- W4232557712 hasConceptScore W4232557712C2776120307 @default.
- W4232557712 hasConceptScore W4232557712C2778048844 @default.
- W4232557712 hasConceptScore W4232557712C2778371730 @default.
- W4232557712 hasConceptScore W4232557712C2780035454 @default.
- W4232557712 hasConceptScore W4232557712C54355233 @default.
- W4232557712 hasConceptScore W4232557712C71924100 @default.
- W4232557712 hasConceptScore W4232557712C86803240 @default.
- W4232557712 hasConceptScore W4232557712C98274493 @default.
- W4232557712 hasLocation W42325577121 @default.
- W4232557712 hasLocation W42325577122 @default.
- W4232557712 hasLocation W42325577123 @default.
- W4232557712 hasOpenAccess W4232557712 @default.
- W4232557712 hasPrimaryLocation W42325577121 @default.
- W4232557712 hasRelatedWork W12217740 @default.
- W4232557712 hasRelatedWork W14276153 @default.
- W4232557712 hasRelatedWork W1771131 @default.
- W4232557712 hasRelatedWork W3102935 @default.
- W4232557712 hasRelatedWork W4926441 @default.
- W4232557712 hasRelatedWork W5012469 @default.
- W4232557712 hasRelatedWork W5368029 @default.
- W4232557712 hasRelatedWork W7239210 @default.
- W4232557712 hasRelatedWork W11359455 @default.
- W4232557712 hasRelatedWork W6989393 @default.
- W4232557712 isParatext "false" @default.
- W4232557712 isRetracted "false" @default.
- W4232557712 workType "article" @default.