Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232565309> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4232565309 endingPage "412" @default.
- W4232565309 startingPage "410" @default.
- W4232565309 abstract "Summary: There is an urgent need for a universally effective HIV-1 vaccine, but whether a vaccine will be able to protect against HIV-1 of different clades is a significant concern. IgA from HIV-1-exposed, persistently seronegative (HEPS) subjects has been shown to neutralize HIV-1 and to block epithelial HIV-1 transcytosis, and it may target novel HIV-1 epitopes. We have tested the ability of plasma and mucosal IgA purified from HEPS subjects to neutralize HIV-1 primary isolates of different viral clades and phenotypes. IgA from two groups of HEPS subjects was tested: sex workers from Nairobi, Kenya, where clades A and D predominate, and the heterosexual partners of individuals infected by clade B virus. HIV-1-infected and low-risk uninfected individuals were included as controls. IgA purified from the blood, genital tract, and saliva of most HEPS sex workers demonstrated significant crossclade HIV-1 neutralization, whereas a more clade-restricted pattern of neutralization was found in partners of clade B-infected individuals. IgA purified from HIV-1-infected individuals also mediated cross-clade neutralization, whereas IgA from uninfected controls lacked neutralizing activity. In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine." @default.
- W4232565309 created "2022-05-12" @default.
- W4232565309 creator A5002775686 @default.
- W4232565309 creator A5016295371 @default.
- W4232565309 creator A5020340000 @default.
- W4232565309 creator A5036894086 @default.
- W4232565309 creator A5038006776 @default.
- W4232565309 creator A5044206468 @default.
- W4232565309 creator A5049263321 @default.
- W4232565309 creator A5054671965 @default.
- W4232565309 creator A5060462160 @default.
- W4232565309 creator A5061284054 @default.
- W4232565309 creator A5068130677 @default.
- W4232565309 date "2002-08-01" @default.
- W4232565309 modified "2023-10-14" @default.
- W4232565309 title "Safety and Efficacy of Saquinavir Soft-Gelatin Capsules + Zidovudine + Optional Lamivudine in Pregnancy and Prevention of Vertical HIV Transmission" @default.
- W4232565309 doi "https://doi.org/10.1097/00126334-200208010-00006" @default.
- W4232565309 hasPublicationYear "2002" @default.
- W4232565309 type Work @default.
- W4232565309 citedByCount "0" @default.
- W4232565309 crossrefType "journal-article" @default.
- W4232565309 hasAuthorship W4232565309A5002775686 @default.
- W4232565309 hasAuthorship W4232565309A5016295371 @default.
- W4232565309 hasAuthorship W4232565309A5020340000 @default.
- W4232565309 hasAuthorship W4232565309A5036894086 @default.
- W4232565309 hasAuthorship W4232565309A5038006776 @default.
- W4232565309 hasAuthorship W4232565309A5044206468 @default.
- W4232565309 hasAuthorship W4232565309A5049263321 @default.
- W4232565309 hasAuthorship W4232565309A5054671965 @default.
- W4232565309 hasAuthorship W4232565309A5060462160 @default.
- W4232565309 hasAuthorship W4232565309A5061284054 @default.
- W4232565309 hasAuthorship W4232565309A5068130677 @default.
- W4232565309 hasConcept C104317684 @default.
- W4232565309 hasConcept C119599485 @default.
- W4232565309 hasConcept C127413603 @default.
- W4232565309 hasConcept C159047783 @default.
- W4232565309 hasConcept C159654299 @default.
- W4232565309 hasConcept C193252679 @default.
- W4232565309 hasConcept C203014093 @default.
- W4232565309 hasConcept C2522874641 @default.
- W4232565309 hasConcept C2778190748 @default.
- W4232565309 hasConcept C2779102806 @default.
- W4232565309 hasConcept C2780195530 @default.
- W4232565309 hasConcept C2780898057 @default.
- W4232565309 hasConcept C3013748606 @default.
- W4232565309 hasConcept C44465124 @default.
- W4232565309 hasConcept C54355233 @default.
- W4232565309 hasConcept C71924100 @default.
- W4232565309 hasConcept C761482 @default.
- W4232565309 hasConcept C86803240 @default.
- W4232565309 hasConceptScore W4232565309C104317684 @default.
- W4232565309 hasConceptScore W4232565309C119599485 @default.
- W4232565309 hasConceptScore W4232565309C127413603 @default.
- W4232565309 hasConceptScore W4232565309C159047783 @default.
- W4232565309 hasConceptScore W4232565309C159654299 @default.
- W4232565309 hasConceptScore W4232565309C193252679 @default.
- W4232565309 hasConceptScore W4232565309C203014093 @default.
- W4232565309 hasConceptScore W4232565309C2522874641 @default.
- W4232565309 hasConceptScore W4232565309C2778190748 @default.
- W4232565309 hasConceptScore W4232565309C2779102806 @default.
- W4232565309 hasConceptScore W4232565309C2780195530 @default.
- W4232565309 hasConceptScore W4232565309C2780898057 @default.
- W4232565309 hasConceptScore W4232565309C3013748606 @default.
- W4232565309 hasConceptScore W4232565309C44465124 @default.
- W4232565309 hasConceptScore W4232565309C54355233 @default.
- W4232565309 hasConceptScore W4232565309C71924100 @default.
- W4232565309 hasConceptScore W4232565309C761482 @default.
- W4232565309 hasConceptScore W4232565309C86803240 @default.
- W4232565309 hasIssue "4" @default.
- W4232565309 hasLocation W42325653091 @default.
- W4232565309 hasOpenAccess W4232565309 @default.
- W4232565309 hasPrimaryLocation W42325653091 @default.
- W4232565309 hasRelatedWork W1487857142 @default.
- W4232565309 hasRelatedWork W1547625320 @default.
- W4232565309 hasRelatedWork W1561127041 @default.
- W4232565309 hasRelatedWork W2062279822 @default.
- W4232565309 hasRelatedWork W2101049386 @default.
- W4232565309 hasRelatedWork W2139983200 @default.
- W4232565309 hasRelatedWork W2147040603 @default.
- W4232565309 hasRelatedWork W2166242021 @default.
- W4232565309 hasRelatedWork W2409733744 @default.
- W4232565309 hasRelatedWork W2608032033 @default.
- W4232565309 hasVolume "30" @default.
- W4232565309 isParatext "false" @default.
- W4232565309 isRetracted "false" @default.
- W4232565309 workType "article" @default.