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- W4232566272 abstract "Spectinomycin is an aminocyclitol antibiotic unique both in structure (1,2) and in biological activity. The antibiotic (Figure 1) is a pseudodisaccharide in which a non-aminosugar moiety, actinospectose, is fused to an aminocyclitol, actinamine or N,N'-dimethy1-2-epi-streptamine by both a β-glycosidic bond and a hemiketal linkage. The bioactivity of spectinomycin resembles that of other aminocyclitol antibiotics only in that its antibacterial spectrum is broad and its mode of action is the inhibition of protein synthesis by an interaction with the 30s ribosomal subunit (3). Spectinomycin's action is generally bacteriostatic rather than bacteriocidal and, although its antibacterial spectrum is described as broad, in vitro potency is generally low. In vivo potency is, however, considerably better than one would predict on the basis of in vitro activity. Most importantly, spectinomycin is devoid of the ototoxic and nephrotoxic properties normally associated with the amino-glycosidic aminocyclitol class of antibiotics (4). In our hands, we have been" @default.
- W4232566272 created "2022-05-12" @default.
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- W4232566272 date "1980-08-04" @default.
- W4232566272 modified "2023-09-26" @default.
- W4232566272 title "Spectinomycin Modification" @default.
- W4232566272 doi "https://doi.org/10.1021/bk-1980-0125.ch008" @default.
- W4232566272 hasPublicationYear "1980" @default.
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