Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232648035> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4232648035 endingPage "913" @default.
- W4232648035 startingPage "913" @default.
- W4232648035 abstract "Electronic Nicotine Delivery Systems (ENDS), i.e., electronic-cigarettes (e-cigs) and Tobacco Heating Products (THPs), are rapidly growing in popularity. Nonetheless, comprehensive quality and safety requirements for regulatory purposes are still under development. Cytotoxicity studies are important initial steps in appraising the potential ENDS toxicity. The aim of the present study was to screen different in vitro cytotoxicity methods for the assessment of ENDS toxicity. We evaluated NRU, MTT, Annexin V apoptosis (AN-V), High-Content Screening (HCS) assays and Real-Time Cell Analysis (RTCA), to compare two e-cigs and two THPs with the 1R6F reference tobacco cigarette. Human adenocarcinoma lung epithelial cells (H292) were exposed to tobacco smoke and ENDS vapor at air-liquid interface. All tests showed reduced cell viability following 1R6F smoke exposure and slight or no reduction with ENDS at 24 h. AN-V and RTCA exhibited a further significant reduction in cell viability following 1R6F exposure. AN-V allowed to discriminate viable cells from those in early/late apoptosis. RTCA and HCS being time-resolved analyses elucidate the kinetic dependency parameter for toxicity of smoke/vapor chemicals on cell viability. In conclusion, NRU assay may be considered a suitable test, especially when combined with a time-resolved analysis, for assessing the kinetic of cytotoxicity induced by these products." @default.
- W4232648035 created "2022-05-12" @default.
- W4232648035 date "1974-12-01" @default.
- W4232648035 modified "2023-10-18" @default.
- W4232648035 title "Fragrance raw materials monographs" @default.
- W4232648035 doi "https://doi.org/10.1016/0015-6264(74)90181-3" @default.
- W4232648035 hasPublicationYear "1974" @default.
- W4232648035 type Work @default.
- W4232648035 citedByCount "1" @default.
- W4232648035 crossrefType "journal-article" @default.
- W4232648035 hasConcept C109316439 @default.
- W4232648035 hasConcept C178790620 @default.
- W4232648035 hasConcept C185592680 @default.
- W4232648035 hasConcept C190283241 @default.
- W4232648035 hasConcept C202751555 @default.
- W4232648035 hasConcept C2776970978 @default.
- W4232648035 hasConcept C2780484033 @default.
- W4232648035 hasConcept C29730261 @default.
- W4232648035 hasConcept C2993351451 @default.
- W4232648035 hasConcept C31903555 @default.
- W4232648035 hasConcept C33070731 @default.
- W4232648035 hasConcept C53227056 @default.
- W4232648035 hasConcept C55493867 @default.
- W4232648035 hasConcept C58874564 @default.
- W4232648035 hasConcept C86803240 @default.
- W4232648035 hasConcept C88634738 @default.
- W4232648035 hasConceptScore W4232648035C109316439 @default.
- W4232648035 hasConceptScore W4232648035C178790620 @default.
- W4232648035 hasConceptScore W4232648035C185592680 @default.
- W4232648035 hasConceptScore W4232648035C190283241 @default.
- W4232648035 hasConceptScore W4232648035C202751555 @default.
- W4232648035 hasConceptScore W4232648035C2776970978 @default.
- W4232648035 hasConceptScore W4232648035C2780484033 @default.
- W4232648035 hasConceptScore W4232648035C29730261 @default.
- W4232648035 hasConceptScore W4232648035C2993351451 @default.
- W4232648035 hasConceptScore W4232648035C31903555 @default.
- W4232648035 hasConceptScore W4232648035C33070731 @default.
- W4232648035 hasConceptScore W4232648035C53227056 @default.
- W4232648035 hasConceptScore W4232648035C55493867 @default.
- W4232648035 hasConceptScore W4232648035C58874564 @default.
- W4232648035 hasConceptScore W4232648035C86803240 @default.
- W4232648035 hasConceptScore W4232648035C88634738 @default.
- W4232648035 hasIssue "7-8" @default.
- W4232648035 hasLocation W42326480351 @default.
- W4232648035 hasOpenAccess W4232648035 @default.
- W4232648035 hasPrimaryLocation W42326480351 @default.
- W4232648035 hasRelatedWork W1974376880 @default.
- W4232648035 hasRelatedWork W1980023517 @default.
- W4232648035 hasRelatedWork W2012998458 @default.
- W4232648035 hasRelatedWork W2369066530 @default.
- W4232648035 hasRelatedWork W2371556958 @default.
- W4232648035 hasRelatedWork W2378294407 @default.
- W4232648035 hasRelatedWork W2937062791 @default.
- W4232648035 hasRelatedWork W3135356660 @default.
- W4232648035 hasRelatedWork W3152295622 @default.
- W4232648035 hasRelatedWork W3184193587 @default.
- W4232648035 hasVolume "12" @default.
- W4232648035 isParatext "false" @default.
- W4232648035 isRetracted "false" @default.
- W4232648035 workType "article" @default.