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- W4232694562 abstract "Objective: To investigate whether botulinum toxin type A (BTX-A) (Botox) treatment increases walking speed in poststroke patients. Design: Part I was an 18- to 20-week, double-blind, placebo-controlled study; part II was a 12-week, open-label follow-up. Setting: 7 clinical sites. Participants: Of 85 original study poststroke patients, the subanalysis included 47 with spastic equinovarus deformity (baseline: Ashworth Scale score, 2−3; walking speed, <10m per 13s). Interventions: Part I patients were randomized to either 200 or 300U of BTX-A or placebo; patients entered part II and received up to 300U of BTX-A at least 12 weeks after the first injection if their Ashworth scores returned to baseline. Patients were assessed at 4-week intervals after each injection. Main Outcome Measure: Percentage of change from baseline in walking speed (calculated as time taken to walk 10m). Results: BTX-A significantly increased walking speed by 18.8%, 14.4%, and 25.8% (P≤.028) after first injection and by 25.9%, 38.8%, and 39.3% (P≤.005) after second injection at 4, 8, and 12 weeks, respectively. Placebo subjects showed a significant increase of 19.8% (P=.026) at 4 weeks; patients receiving first BTX-A injection in part II showed significant increase of 35.5% (P=.04) at 12 weeks. BTX-A was safe and well-tolerated. Conclusions: BTX-A significantly improved walking speed in poststroke patients." @default.
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- W4232694562 date "2007-10-01" @default.
- W4232694562 modified "2023-10-18" @default.
- W4232694562 title "Poster 4: Effect of Botulinum Toxin Type A on Walking Speed in Poststroke Patients: A Subgroup Analysis of Patients in a 2-Part, 32-Week, Multicenter Study" @default.
- W4232694562 doi "https://doi.org/10.1016/j.apmr.2007.08.043" @default.
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