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- W4232747889 abstract "Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that Wnt pathway transcription factor T-cell factor 7, TCF7, encoding for TCF1, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that TCF7 was also differentially expressed in brain metastatic tissues. TCF7 mRNA was present at increased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of TCF7 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node negative patients but not in lymph node positive patients. Modulation of TCF7/TCF1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer." @default.
- W4232747889 created "2022-05-12" @default.
- W4232747889 creator A5024900493 @default.
- W4232747889 date "2021-02-07" @default.
- W4232747889 modified "2023-09-25" @default.
- W4232747889 title "TCF7 (TCF1) is differentially expressed in the lymph nodes of patients with metastatic breast cancer." @default.
- W4232747889 doi "https://doi.org/10.31219/osf.io/dt9k3" @default.
- W4232747889 hasPublicationYear "2021" @default.
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