Matches in SemOpenAlex for { <https://semopenalex.org/work/W4232783508> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4232783508 endingPage "592" @default.
- W4232783508 startingPage "580" @default.
- W4232783508 abstract "Objective The authors hypothesized that pancreaticogastrostomy is safer than pancreaticojejunostomy after pancreaticoduodenectomy and less likely to be associated with a postoperative pancreatic fistula. Summary Background Data Pancreatic fistula is a leading cause of morbidity and mortality after pancreaticoduodenectomy, occurring in 10% to 20% of patients. Nonrandomized reports have suggested that pancreaticogastrostomy is less likely than pancreaticojejunostomy to be associated with postoperative complications. Methods Between May 1993 and January 1995, the findings for 145 patients were analyzed in this prospective trial at The Johns Hopkins Hospital. After giving their appropriate preoperative informed consent, patients were randomly assigned to pancreaticogastrostomy or pancreaticojejunostomy after completion of the pancreaticoduodenal resection. All pancreatic anastomoses were performed in two layers without pancreatic duct stents and with closed suction drainage. Pancreatic fistula was defined as drainage of greater than 50 mL of amylase-rich fluid on or after postoperative day 10. Results The pancreaticogastrostomy (n = 73) and pancreaticojejunostomy (n = 72) groups were comparable with regard to multiple parameters, including demographics, medical history, preoperative laboratory values, and intraoperative factors, such as operative time, blood transfusions, pancreatic texture, length of pancreatic remnant mobilized, and pancreatic duct diameter. The overall incidence of pancreatic fistula after pancreaticoduodenectomy was 11.7% (17/145). The incidence of pancreatic fistula was similar for the pancreaticogastrostomy (12.3%) and pancreaticojejunostomy (11.1%) groups. Pancreatic fistula was associated with a significant prolongation of postoperative hospital stay (36 ± 5 vs. 15 ± 1 days) (p < 0.001). Factors significantly increasing the risk of pancreatic fistula by univariate logistic regression analysis included ampullary or duodenal disease, soft pancreatic texture, longer operative time, greater intraoperative red blood cell transfusions, and lower surgical volume (p < 0.05). A multivariate logistic regression analysis revealed the factors most highly associated with pancreatic fistula to be lower surgical volume and ampullary or duodenal disease in the resected specimen. Conclusions Pancreatic fistula is a common complication after pancreaticoduodenectomy, with an incidence most strongly associated with surgical volume and underlying disease. These data do not support the hypothesis that pancreaticogastrostomy is safer than pancreaticojejunostomy or is associated with a lower incidence of pancreatic fistula." @default.
- W4232783508 created "2022-05-12" @default.
- W4232783508 creator A5011555598 @default.
- W4232783508 creator A5015920018 @default.
- W4232783508 creator A5025415933 @default.
- W4232783508 creator A5026919131 @default.
- W4232783508 creator A5049057554 @default.
- W4232783508 creator A5051782291 @default.
- W4232783508 creator A5060234674 @default.
- W4232783508 creator A5066262953 @default.
- W4232783508 date "1995-10-01" @default.
- W4232783508 modified "2023-09-27" @default.
- W4232783508 title "A Prospective Randomized Trial of Pancreaticogastrostomy Versus Pancreaticojejunostomy After Pancreaticoduodenectomy" @default.
- W4232783508 doi "https://doi.org/10.1097/00000658-199522240-00014" @default.
- W4232783508 hasPublicationYear "1995" @default.
- W4232783508 type Work @default.
- W4232783508 citedByCount "10" @default.
- W4232783508 countsByYear W42327835082015 @default.
- W4232783508 countsByYear W42327835082021 @default.
- W4232783508 crossrefType "journal-article" @default.
- W4232783508 hasAuthorship W4232783508A5011555598 @default.
- W4232783508 hasAuthorship W4232783508A5015920018 @default.
- W4232783508 hasAuthorship W4232783508A5025415933 @default.
- W4232783508 hasAuthorship W4232783508A5026919131 @default.
- W4232783508 hasAuthorship W4232783508A5049057554 @default.
- W4232783508 hasAuthorship W4232783508A5051782291 @default.
- W4232783508 hasAuthorship W4232783508A5060234674 @default.
- W4232783508 hasAuthorship W4232783508A5066262953 @default.
- W4232783508 hasConcept C126322002 @default.
- W4232783508 hasConcept C141071460 @default.
- W4232783508 hasConcept C159110652 @default.
- W4232783508 hasConcept C188816634 @default.
- W4232783508 hasConcept C2775967933 @default.
- W4232783508 hasConcept C2776341189 @default.
- W4232783508 hasConcept C2776737053 @default.
- W4232783508 hasConcept C2778764654 @default.
- W4232783508 hasConcept C2778975757 @default.
- W4232783508 hasConcept C2779960720 @default.
- W4232783508 hasConcept C2780911694 @default.
- W4232783508 hasConcept C71924100 @default.
- W4232783508 hasConcept C8443397 @default.
- W4232783508 hasConceptScore W4232783508C126322002 @default.
- W4232783508 hasConceptScore W4232783508C141071460 @default.
- W4232783508 hasConceptScore W4232783508C159110652 @default.
- W4232783508 hasConceptScore W4232783508C188816634 @default.
- W4232783508 hasConceptScore W4232783508C2775967933 @default.
- W4232783508 hasConceptScore W4232783508C2776341189 @default.
- W4232783508 hasConceptScore W4232783508C2776737053 @default.
- W4232783508 hasConceptScore W4232783508C2778764654 @default.
- W4232783508 hasConceptScore W4232783508C2778975757 @default.
- W4232783508 hasConceptScore W4232783508C2779960720 @default.
- W4232783508 hasConceptScore W4232783508C2780911694 @default.
- W4232783508 hasConceptScore W4232783508C71924100 @default.
- W4232783508 hasConceptScore W4232783508C8443397 @default.
- W4232783508 hasIssue "4" @default.
- W4232783508 hasLocation W42327835081 @default.
- W4232783508 hasOpenAccess W4232783508 @default.
- W4232783508 hasPrimaryLocation W42327835081 @default.
- W4232783508 hasRelatedWork W1975888688 @default.
- W4232783508 hasRelatedWork W2027425058 @default.
- W4232783508 hasRelatedWork W2090261041 @default.
- W4232783508 hasRelatedWork W2243670315 @default.
- W4232783508 hasRelatedWork W2327972863 @default.
- W4232783508 hasRelatedWork W2366837850 @default.
- W4232783508 hasRelatedWork W2566229490 @default.
- W4232783508 hasRelatedWork W2587584476 @default.
- W4232783508 hasRelatedWork W2921559678 @default.
- W4232783508 hasRelatedWork W3062527655 @default.
- W4232783508 hasVolume "222" @default.
- W4232783508 isParatext "false" @default.
- W4232783508 isRetracted "false" @default.
- W4232783508 workType "article" @default.