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• W4232821306 abstract "We report toxic effects of a photoactivatable platinum(IV) complex conjugated with suberoyl-bis-hydroxamic acid in tumor cells. The conjugate exerts, after photoactivation, two functions: activity as both a platinum(II) anticancer drug and histone deacetylase (HDAC) inhibitor in cancer cells. This approach relies on the use of a PtIV pro-drug, acting by two independent mechanisms of biological action in a cooperative manner, which can be selectively photoactivated to a cytotoxic species in and around a tumor, thereby increasing selectivity towards cancer cells. These results suggest that this strategy is a valuable route to design new platinum agents with higher efficacy for photodynamic anticancer chemotherapy." @default.
• W4232821306 created "2022-05-12" @default.
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• W4232821306 date "2015-10-12" @default.
• W4232821306 modified "2023-10-16" @default.
• W4232821306 title "A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases" @default.
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• W4232821306 doi "https://doi.org/10.1002/ange.201506533" @default.
• W4232821306 hasPublicationYear "2015" @default.
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