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- W4232835331 abstract "Inflammatory demyelinating neuropathy (IDN) is a rare immune-mediated neurological disease of the peripheral nerve system. The exact cause and pathogenesis are not yet understood. It is presumed that myelin sheath surrounding the axons is attacked by the immune system. This likely results from antibody-mediated reaction along with infiltration of the endoneurium with T-cell lymphocytes and macrophages. The end consequence of this process is a segmental demyelination with inflammation. Patients clinically present with slowly progressive sensory and motor deficits. Cranial nerve and respiratory muscle involvements rarely occur. The hallmark sign for the diagnosis is evidence of demyelination and inflammation seen in electrodiagnostic studies and nerve biopsy, respectively. In this chapter, we describe the diagnostic and histopathological features of acute and chronic IDN. We also discuss the histological tricks to distinguish this disease from axonal degeneration (with secondary demyelination) and vasculitic neuropathy." @default.
- W4232835331 created "2022-05-12" @default.
- W4232835331 creator A5067672260 @default.
- W4232835331 date "2021-03-18" @default.
- W4232835331 modified "2023-09-23" @default.
- W4232835331 title "Inflammatory Demyelination" @default.
- W4232835331 cites W2009265266 @default.
- W4232835331 doi "https://doi.org/10.1201/9781003119135-32" @default.
- W4232835331 hasPublicationYear "2021" @default.
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