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- W4232877906 abstract "Importin β, once thought to be exclusively a nuclear transport receptor, is emerging as a global regulator of diverse cellular functions. Importin β acts positively in multiple interphase roles: in nuclear import, as a chaperone for highly charged nuclear proteins, and as a potential motor adaptor for movement along microtubules. In contrast, importin β plays a negative regulatory role in mitotic spindle assembly, centrosome dynamics, nuclear membrane formation, and nuclear pore assembly. In most of these, importin β is counteracted by its regulator, Ran-GTP. In light of this, the recent discovery of Ran's involvement in spindle checkpoint control suggested a potential new arena for importin β action, although it is also possible that one of importin β's relatives, the karyopherin family of proteins, manages this checkpoint. Lastly, importin β plays a role in transducing damage signals from the axons of injured neurons back to the cell body." @default.
- W4232877906 created "2022-05-12" @default.
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- W4232877906 date "2004-11-05" @default.
- W4232877906 modified "2023-10-15" @default.
- W4232877906 title "Importin BetaConducting a Much Larger Cellular Symphony" @default.
- W4232877906 doi "https://doi.org/10.1016/s1097-2765(04)00647-1" @default.
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