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- W4233076738 abstract "Abstract Background: Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Methods: 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t- test or Nonparametric test was used to detect differences between PCOS and control groups.Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Results: Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95 %). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR." @default.
- W4233076738 created "2022-05-12" @default.
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- W4233076738 date "2020-04-15" @default.
- W4233076738 modified "2023-10-16" @default.
- W4233076738 title "Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome" @default.
- W4233076738 doi "https://doi.org/10.21203/rs.2.24005/v3" @default.
- W4233076738 hasPublicationYear "2020" @default.
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