Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233088082> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4233088082 endingPage "732" @default.
- W4233088082 startingPage "729" @default.
- W4233088082 abstract "Lipases are water-soluble, ester hydrolases that are traditionally defined by their marked preference for apolar, water-insoluble ester substrates. This group of enzymes also includes species referred to as cholesterol esterases. Lipases and cholesterol esterases are distinguished from phospholipases that catalyze the hydrolysis of acyl ester bonds of highly amphipathic phospholipids having an sn-glycero-3-phospho-X moiety and from carboxylesterases that hydrolyze polar, water-soluble esters. These distinctions are relative, however, because some lipases exhibit activity toward phospholipids or soluble esters. Typical natural lipase substrates include, in order of amphipathicity, long aliphatic chain acyl esters of cholesterol (cholesteryl esters), triacyl esters of glycerol (triacylglycerols), acyl esters of long chain alcohols (wax esters), diacyl esters of glycerol (diacylglycerols), and monoacyl esters of glycerol. Because lipase substrates tend to be oily and only weakly amphipathic, they reside primarily in a bulk oil phase in preference to the aqueous phase or to the interface, that is, monomolecular surface phase that separates the bulk oil and aqueous phases. It follows, because lipases are water-soluble enzymes, that the site of lipolysis is the quasi-two-dimensional interface. The focus of basic research on lipases has been to understand how a reaction involving such a change in dimensionality can occur and how it is regulated. Medically, lipases are targets for therapeutic intervention in the treatment of obesity. The focus of applied research with lipases has been to exploit the unusual properties of lipolytic systems for the production of chiral pharmaceuticals, improved detergents, and designer fats." @default.
- W4233088082 created "2022-05-12" @default.
- W4233088082 creator A5012667458 @default.
- W4233088082 date "2013-01-01" @default.
- W4233088082 modified "2023-10-16" @default.
- W4233088082 title "Lipases" @default.
- W4233088082 cites W1990632444 @default.
- W4233088082 cites W2006425615 @default.
- W4233088082 cites W2017025152 @default.
- W4233088082 cites W2040711961 @default.
- W4233088082 cites W2142142781 @default.
- W4233088082 doi "https://doi.org/10.1016/b978-0-12-378630-2.00118-3" @default.
- W4233088082 hasPublicationYear "2013" @default.
- W4233088082 type Work @default.
- W4233088082 citedByCount "2" @default.
- W4233088082 countsByYear W42330880822023 @default.
- W4233088082 crossrefType "book-chapter" @default.
- W4233088082 hasAuthorship W4233088082A5012667458 @default.
- W4233088082 hasConcept C140985366 @default.
- W4233088082 hasConcept C149556010 @default.
- W4233088082 hasConcept C171089720 @default.
- W4233088082 hasConcept C178790620 @default.
- W4233088082 hasConcept C181199279 @default.
- W4233088082 hasConcept C184651966 @default.
- W4233088082 hasConcept C185592680 @default.
- W4233088082 hasConcept C2776568683 @default.
- W4233088082 hasConcept C2779542420 @default.
- W4233088082 hasConcept C2779697368 @default.
- W4233088082 hasConcept C2780881558 @default.
- W4233088082 hasConcept C55493867 @default.
- W4233088082 hasConcept C94412978 @default.
- W4233088082 hasConceptScore W4233088082C140985366 @default.
- W4233088082 hasConceptScore W4233088082C149556010 @default.
- W4233088082 hasConceptScore W4233088082C171089720 @default.
- W4233088082 hasConceptScore W4233088082C178790620 @default.
- W4233088082 hasConceptScore W4233088082C181199279 @default.
- W4233088082 hasConceptScore W4233088082C184651966 @default.
- W4233088082 hasConceptScore W4233088082C185592680 @default.
- W4233088082 hasConceptScore W4233088082C2776568683 @default.
- W4233088082 hasConceptScore W4233088082C2779542420 @default.
- W4233088082 hasConceptScore W4233088082C2779697368 @default.
- W4233088082 hasConceptScore W4233088082C2780881558 @default.
- W4233088082 hasConceptScore W4233088082C55493867 @default.
- W4233088082 hasConceptScore W4233088082C94412978 @default.
- W4233088082 hasLocation W42330880821 @default.
- W4233088082 hasOpenAccess W4233088082 @default.
- W4233088082 hasPrimaryLocation W42330880821 @default.
- W4233088082 hasRelatedWork W146385131 @default.
- W4233088082 hasRelatedWork W1978589186 @default.
- W4233088082 hasRelatedWork W2017351360 @default.
- W4233088082 hasRelatedWork W2017914427 @default.
- W4233088082 hasRelatedWork W2045459028 @default.
- W4233088082 hasRelatedWork W2087979969 @default.
- W4233088082 hasRelatedWork W2171032190 @default.
- W4233088082 hasRelatedWork W2400080905 @default.
- W4233088082 hasRelatedWork W2433049698 @default.
- W4233088082 hasRelatedWork W4239226319 @default.
- W4233088082 isParatext "false" @default.
- W4233088082 isRetracted "false" @default.
- W4233088082 workType "book-chapter" @default.