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- W4233104009 abstract "The nucleotide analogues (S)-9-((3-hydroxy-2-phosphonylmethoxy) propyl)adenine (HPMPA, 1), (S)-9-((3-hydroxy-2-phosphonylmethoxy)propyl)guanine (HPMPG, 3) and (S)-1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine (HPMPC, 4) have been synthesized on a multigram scale and evaluated in vitro and in vivo for antiviral efficacy against herpesviruses. HPMPC emerged as the most selective antiherpes agent of this series. It showed a much greater in vivo efficacy than acyclovir against herpes simplex virus types 1 and 2 and also was more potent than ganciclovir in a murine cytomegalovirus infection model." @default.
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- W4233104009 date "1989-08-22" @default.
- W4233104009 modified "2023-09-27" @default.
- W4233104009 title "Synthesis and Antiviral Activity of Nucleotide Analogues Bearing the (<i>S</i>)-(3-Hydroxy-2-phosphonylmethoxy)propyl Moiety Attached to Adenine, Guanine, and Cytosine" @default.
- W4233104009 doi "https://doi.org/10.1021/bk-1989-0401.ch006" @default.
- W4233104009 hasPublicationYear "1989" @default.
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