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- W4233122824 abstract "Casado-Arroyo et al (J Am Coll Cardiol 2016;68:614, PMID 27491905) evaluated the outcomes of Brugada probands diagnosed from 1986 to 2014. This included 447 probands of families with a diagnostic type 1 electrocardiogram Brugada pattern. The database was divided into 2 periods: 1986–2002 (early group) and 2003–2014 (latter group). There were 165 probands in the early group and 282 in the latter group. Aborted sudden death as the initial manifestation of the disease occurred in 12.1% of the early group vs 4.6% of the latter group (P = .005). Inducibility during programmed electrical stimulation was achieved in 34.4% and 19.2% of patients in the early and latter groups, respectively (P < .001). A spontaneous type 1 electrocardiogram pattern at diagnosis was present in 50.3% of the early group vs 26.2% of the latter group (P = .0002). Patients in the early group had a higher probability of recurrent arrhythmia (19%) than those in the latter group (5%) (P = .007). The use of a sodium-channel blocker to unmask Brugada syndrome allowed earlier diagnoses in many patients. The authors conclude that there has been a decrease in aborted sudden cardiac death as the first manifestation of the disease in patients who were more recently diagnosed." @default.
- W4233122824 created "2022-05-12" @default.
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- W4233122824 date "2016-11-01" @default.
- W4233122824 modified "2023-09-25" @default.
- W4233122824 title "EP News: Clinical" @default.
- W4233122824 doi "https://doi.org/10.1016/j.hrthm.2016.09.004" @default.
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