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• W4233142196 abstract "Molecular imaging today, both in research and in clinical practice, is an increasingly important tool for diagnosis and therapy control of a variety of diseases. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) possess an exceptional position among these methods. In contrast to computed tomography (CT) and magnetic resonance imaging (MRI), which provide mainly morphological information, SPECT and PET allow the visualization of biochemical parameters, such as receptor availability, enzymatic reaction rates, and metabolic pathways. To measure these functional parameters both modalities make use of radioactive tracers as imaging probes. Because of the high sensitivity of photon detection and the resulting ultralow mass of the probes applied, pharmacological effects normally do not occur. As these radiotracers play an important role in both imaging methods, the production and properties of the radioisotopes and the syntheses of the tracers significantly influence the quality of the information gained; the syntheses of the most relevant ones are discussed in this chapter. A comprehensive review of the whole radiochemistry of PET and SPECT radiopharmaceuticals, however, is by far beyond the scope of this chapter. A number of excellent reviews have been published recently, e.g., on general aspects of radiopharmaceutical chemistry (Rsch, Handbook of nuclear chemistry, vol. 4, Kluwer Academic Publishers, The Netherlands, 2003, Saha, Fundamentals of nuclear pharmacy, 5th ed., Springer, New York, 2004) and PET (Miller et al., Angew Chem Int Ed 47:8998-9033, 2008, Saha, Basics of PET imaging, Springer, New York, 2005, Ro and Amatamey, PET chemistry: radiopharmaceuticals, Basic Sciences of Nuclear Medicine, Springer, Heidelberg, 2011) for neuroreceptor imaging (Frankle et al., Neuroimaging B 67:385-440, 2005), on the production of PET radiopharmaceuticals (Stcklin and Pike, Radiopharmaceuticals for positron emission tomography. Kluwer Academic publishers, Dordrecht, 1993), on different aspects of radiotracer synthesis (Fowler and Wolf, Acc Chem Res 30:181-188, 1997), to mention only a few of them. Therefore, the radiochemistry presented in this chapter is limited to radionuclides, relevant for the molecular imaging of neurological processes." @default.
• W4233142196 created "2022-05-12" @default.
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• W4233142196 date "2012-01-01" @default.
• W4233142196 modified "2023-09-30" @default.
• W4233142196 title "Radiopharmaceutical Chemistry" @default.
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• W4233142196 doi "https://doi.org/10.1007/7657_2012_41" @default.
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