Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233189857> ?p ?o ?g. }
- W4233189857 endingPage "412" @default.
- W4233189857 startingPage "405" @default.
- W4233189857 abstract "Abstract Context.—Pancreatic cancer is one of the leading causes of cancer-related deaths. Most cases are diagnosed at an advanced stage when the disease is beyond surgical intervention. Molecular studies during the past decade have contributed greatly to our understanding of this disease. Various germ-line and somatic mutations associated with pancreatic cancers have been characterized, along with abnormal variations in the gene expression patterns. A thorough characterization of molecular alterations such as genetic and epigenetic changes, alterations in the expression of genes and changes in proteins, and posttranslational modifications in pancreatic cancer could lead to a better understanding of its pathogenesis. Objective.—To provide an overview of the various molecular alterations in pancreatic cancer and the methodologies used to catalog such alterations. Data Sources.—Published studies about various molecular alterations at the genomic, epigenetic, transcriptomic, and proteomic levels in pancreatic cancer. Conclusions.—The available data from pancreatic cancer suggests that there are a large number of molecular alterations at genomic, epigenetic, transcriptomic, and proteomic levels. It is now possible to initiate a systems approach to studying pancreatic cancer especially in light of newer initiatives to dissect the pancreatic cancer genome." @default.
- W4233189857 created "2022-05-12" @default.
- W4233189857 creator A5024268602 @default.
- W4233189857 creator A5064601717 @default.
- W4233189857 creator A5085532232 @default.
- W4233189857 date "2009-03-01" @default.
- W4233189857 modified "2023-10-09" @default.
- W4233189857 title "Molecular Alterations in Exocrine Neoplasms of the Pancreas" @default.
- W4233189857 cites W134625928 @default.
- W4233189857 cites W1541204401 @default.
- W4233189857 cites W1560979799 @default.
- W4233189857 cites W1572057058 @default.
- W4233189857 cites W1586738141 @default.
- W4233189857 cites W1820106848 @default.
- W4233189857 cites W1969965692 @default.
- W4233189857 cites W1970552088 @default.
- W4233189857 cites W1971695831 @default.
- W4233189857 cites W1971920749 @default.
- W4233189857 cites W1972818536 @default.
- W4233189857 cites W1975304818 @default.
- W4233189857 cites W1975852886 @default.
- W4233189857 cites W1976824355 @default.
- W4233189857 cites W1977467011 @default.
- W4233189857 cites W1980298474 @default.
- W4233189857 cites W1980447806 @default.
- W4233189857 cites W1980593913 @default.
- W4233189857 cites W1980741832 @default.
- W4233189857 cites W1981104423 @default.
- W4233189857 cites W1981667569 @default.
- W4233189857 cites W1992928961 @default.
- W4233189857 cites W1993301344 @default.
- W4233189857 cites W1995851961 @default.
- W4233189857 cites W1997162169 @default.
- W4233189857 cites W1997537717 @default.
- W4233189857 cites W1997929924 @default.
- W4233189857 cites W1998927459 @default.
- W4233189857 cites W2010005314 @default.
- W4233189857 cites W2010054443 @default.
- W4233189857 cites W2018510608 @default.
- W4233189857 cites W2018519520 @default.
- W4233189857 cites W2018851438 @default.
- W4233189857 cites W2020080445 @default.
- W4233189857 cites W2022195700 @default.
- W4233189857 cites W2023338362 @default.
- W4233189857 cites W2024466061 @default.
- W4233189857 cites W2025542867 @default.
- W4233189857 cites W2027003058 @default.
- W4233189857 cites W2030504358 @default.
- W4233189857 cites W2034629898 @default.
- W4233189857 cites W2036396469 @default.
- W4233189857 cites W2037195518 @default.
- W4233189857 cites W2039442394 @default.
- W4233189857 cites W2040604172 @default.
- W4233189857 cites W2040655951 @default.
- W4233189857 cites W2043250740 @default.
- W4233189857 cites W2045039141 @default.
- W4233189857 cites W2046577405 @default.
- W4233189857 cites W2048083030 @default.
- W4233189857 cites W2051227958 @default.
- W4233189857 cites W2053799156 @default.
- W4233189857 cites W2054025747 @default.
- W4233189857 cites W2054302145 @default.
- W4233189857 cites W2055085803 @default.
- W4233189857 cites W2056685208 @default.
- W4233189857 cites W2059256055 @default.
- W4233189857 cites W2059330620 @default.
- W4233189857 cites W2064243590 @default.
- W4233189857 cites W2064446750 @default.
- W4233189857 cites W2065673022 @default.
- W4233189857 cites W2066135299 @default.
- W4233189857 cites W2069441798 @default.
- W4233189857 cites W2073897377 @default.
- W4233189857 cites W2079251691 @default.
- W4233189857 cites W2079718648 @default.
- W4233189857 cites W2084239507 @default.
- W4233189857 cites W2087389479 @default.
- W4233189857 cites W2087457210 @default.
- W4233189857 cites W2088498795 @default.
- W4233189857 cites W2090642125 @default.
- W4233189857 cites W2095421246 @default.
- W4233189857 cites W2100522747 @default.
- W4233189857 cites W2100801124 @default.
- W4233189857 cites W2101259235 @default.
- W4233189857 cites W2103459879 @default.
- W4233189857 cites W2103953318 @default.
- W4233189857 cites W2108100098 @default.
- W4233189857 cites W2112603564 @default.
- W4233189857 cites W2113386816 @default.
- W4233189857 cites W2114787622 @default.
- W4233189857 cites W2115777959 @default.
- W4233189857 cites W2116201301 @default.
- W4233189857 cites W2120014725 @default.
- W4233189857 cites W2126663928 @default.
- W4233189857 cites W2127180119 @default.
- W4233189857 cites W2127826757 @default.
- W4233189857 cites W2130979840 @default.
- W4233189857 cites W2133654949 @default.
- W4233189857 cites W2134528192 @default.