Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233264881> ?p ?o ?g. }
- W4233264881 abstract "Abstract The 5′‐adenosylcobalamin dependent methylmalonyl‐CoA mutase (MCM) catalyzes the reversible and stereospecific equilibration of ( 2R )‐methylmalonyl CoA and succinyl CoA through a radical mechanism. Its occurrence ranges from bacteria to mammals, where it is required for the metabolism or biosynthesis of propionate. MCM from Propionibacterium shermanii is an αβ‐heterodimer of total molecular weight 150 kDa, containing an inactive β‐subunit along with an active α‐subunit, the latter binding one adenosylcobalamin molecule close to the active site. The protein was found to occur in two fundamentally different conformations: in the presence of substrates it crystallizes in a “closed” conformation, whereas in the absence of substrates an “open” conformation is observed. This dramatic conformational change suggests a mechanism for the first step of the MCM‐catalyzed reaction cycle, i.e. the substrate‐induced homolysis of the Co–C bond." @default.
- W4233264881 created "2022-05-12" @default.
- W4233264881 creator A5012490151 @default.
- W4233264881 creator A5027940353 @default.
- W4233264881 date "2004-03-05" @default.
- W4233264881 modified "2023-10-03" @default.
- W4233264881 title "Methylmalonyl <scp>Co</scp> <scp>A</scp> Mutase" @default.
- W4233264881 cites W1022541426 @default.
- W4233264881 cites W1167924770 @default.
- W4233264881 cites W1482566901 @default.
- W4233264881 cites W1489591984 @default.
- W4233264881 cites W1513875648 @default.
- W4233264881 cites W1514589587 @default.
- W4233264881 cites W1576592708 @default.
- W4233264881 cites W1585123031 @default.
- W4233264881 cites W1606860257 @default.
- W4233264881 cites W1749026910 @default.
- W4233264881 cites W184269733 @default.
- W4233264881 cites W1881281939 @default.
- W4233264881 cites W189404088 @default.
- W4233264881 cites W1934685598 @default.
- W4233264881 cites W1963578268 @default.
- W4233264881 cites W1965126599 @default.
- W4233264881 cites W1968199859 @default.
- W4233264881 cites W1970183481 @default.
- W4233264881 cites W1970714097 @default.
- W4233264881 cites W1972400761 @default.
- W4233264881 cites W1977594354 @default.
- W4233264881 cites W1978871721 @default.
- W4233264881 cites W1979453863 @default.
- W4233264881 cites W1981708356 @default.
- W4233264881 cites W1983164532 @default.
- W4233264881 cites W1983372377 @default.
- W4233264881 cites W1984088416 @default.
- W4233264881 cites W1988099644 @default.
- W4233264881 cites W1997767412 @default.
- W4233264881 cites W2000919500 @default.
- W4233264881 cites W2002520214 @default.
- W4233264881 cites W2006944996 @default.
- W4233264881 cites W2009961755 @default.
- W4233264881 cites W2011551228 @default.
- W4233264881 cites W2014739751 @default.
- W4233264881 cites W2014933705 @default.
- W4233264881 cites W2015724287 @default.
- W4233264881 cites W2017873516 @default.
- W4233264881 cites W2020603677 @default.
- W4233264881 cites W2022235678 @default.
- W4233264881 cites W2024603528 @default.
- W4233264881 cites W2028231353 @default.
- W4233264881 cites W2038527823 @default.
- W4233264881 cites W2039480994 @default.
- W4233264881 cites W2039698050 @default.
- W4233264881 cites W2046152699 @default.
- W4233264881 cites W2046902548 @default.
- W4233264881 cites W2048036692 @default.
- W4233264881 cites W2050514409 @default.
- W4233264881 cites W2051134821 @default.
- W4233264881 cites W2052886486 @default.
- W4233264881 cites W2053731321 @default.
- W4233264881 cites W2054283424 @default.
- W4233264881 cites W2068497257 @default.
- W4233264881 cites W2068591304 @default.
- W4233264881 cites W2070797743 @default.
- W4233264881 cites W2072447108 @default.
- W4233264881 cites W2080346236 @default.
- W4233264881 cites W2080528351 @default.
- W4233264881 cites W2087785373 @default.
- W4233264881 cites W2090387133 @default.
- W4233264881 cites W2092324522 @default.
- W4233264881 cites W2093992232 @default.
- W4233264881 cites W2095013747 @default.
- W4233264881 cites W2098772291 @default.
- W4233264881 cites W2099101624 @default.
- W4233264881 cites W2110618811 @default.
- W4233264881 cites W2111413667 @default.
- W4233264881 cites W2114760287 @default.
- W4233264881 cites W2139848390 @default.
- W4233264881 cites W2142885692 @default.
- W4233264881 cites W2154602622 @default.
- W4233264881 cites W2158023121 @default.
- W4233264881 cites W2159408764 @default.
- W4233264881 cites W2164425579 @default.
- W4233264881 cites W2165388978 @default.
- W4233264881 cites W2200172635 @default.
- W4233264881 cites W2214192771 @default.
- W4233264881 cites W2301273031 @default.
- W4233264881 cites W2334099322 @default.
- W4233264881 cites W2341391966 @default.
- W4233264881 cites W2952015601 @default.
- W4233264881 cites W3005472204 @default.
- W4233264881 cites W3206291250 @default.
- W4233264881 cites W4231076736 @default.
- W4233264881 doi "https://doi.org/10.1002/9781119951438.eibc0599" @default.
- W4233264881 hasPublicationYear "2004" @default.
- W4233264881 type Work @default.
- W4233264881 citedByCount "1" @default.
- W4233264881 countsByYear W42332648812016 @default.
- W4233264881 crossrefType "other" @default.
- W4233264881 hasAuthorship W4233264881A5012490151 @default.
- W4233264881 hasAuthorship W4233264881A5027940353 @default.