FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233265714> ?p ?o ?g. }

• W4233265714 endingPage "108" @default.
• W4233265714 startingPage "102" @default.
• W4233265714 abstract "Abstract. Indomethacin (IND), a nonsteroidal anti-inflammatory drug, has been known to cause gastric mucosal injury as a side effect. Using a rat gastric mucosal cell line, RGM1, we determined whether apoptosis is involved in IND-mediated gastropathy, and whether caspase activation and mitochondrial cytochrome c release play an important role in producing apoptosis of IND-treated RGM1 cells in the presence of serum. IND caused caspase-3-like protease activation followed by apoptosis in a dose- and time-dependent manner. Caspase-1-like protease activity did not change during IND-induced apoptosis. IND also increased mitochondrial cytochrome c release in a time-dependent fashion. Mitochondrial cytochrome c efflux occurred just before or at the same time as caspase-3-like protease activation, and preceded the increase in apoptotic cell numbers. Z-VAD-FMK, a caspase inhibitor, inhibited both the increase in caspase-3-like protease activity and apoptosis in IND-treated RGM1 cells but did not affect caspase-1-like protease activity or mitochondrial cytochrome c release. These observations suggest that the apoptosis of gastric mucosal cells could be involved in IND-induced gastropathy, that cytochrome c is released from mitochondria into the cytosol during the early phase of IND-mediated apoptosis, and that subsequent activation of caspase-3-like protease, but not caspase-1-like protease, is required for the execution of apoptosis." @default.
• W4233265714 created "2022-05-12" @default.
• W4233265714 creator A5002183495 @default.
• W4233265714 creator A5003220233 @default.
• W4233265714 creator A5008400314 @default.
• W4233265714 creator A5009328617 @default.
• W4233265714 creator A5026002617 @default.
• W4233265714 creator A5047868880 @default.
• W4233265714 date "2008-07-18" @default.
• W4233265714 modified "2023-10-17" @default.
• W4233265714 title "Mitochondrial Cytochrome c Release and Caspase-3-Like Protease Activation During Indomethacin-Induced Apoptosis in Rat Gastric Mucosal Cells" @default.
• W4233265714 cites W1648593433 @default.
• W4233265714 cites W1942214720 @default.
• W4233265714 cites W1970757709 @default.
• W4233265714 cites W1975427274 @default.
• W4233265714 cites W1977707442 @default.
• W4233265714 cites W1979995768 @default.
• W4233265714 cites W1989602122 @default.
• W4233265714 cites W1991945233 @default.
• W4233265714 cites W1992580705 @default.
• W4233265714 cites W1997005484 @default.
• W4233265714 cites W2002408632 @default.
• W4233265714 cites W2008374272 @default.
• W4233265714 cites W2008574207 @default.
• W4233265714 cites W2012173926 @default.
• W4233265714 cites W2012810767 @default.
• W4233265714 cites W2013314062 @default.
• W4233265714 cites W2022371229 @default.
• W4233265714 cites W2022381285 @default.
• W4233265714 cites W2035548685 @default.
• W4233265714 cites W2043944220 @default.
• W4233265714 cites W2057739013 @default.
• W4233265714 cites W2061846257 @default.
• W4233265714 cites W2071948579 @default.
• W4233265714 cites W2072858020 @default.
• W4233265714 cites W2077459776 @default.
• W4233265714 cites W2082031131 @default.
• W4233265714 cites W2095105178 @default.
• W4233265714 cites W2102998161 @default.
• W4233265714 cites W2110925122 @default.
• W4233265714 cites W2113999599 @default.
• W4233265714 cites W2123945814 @default.
• W4233265714 cites W2130866079 @default.
• W4233265714 cites W2149967205 @default.
• W4233265714 cites W2150476216 @default.
• W4233265714 cites W2154346380 @default.
• W4233265714 cites W2327667256 @default.
• W4233265714 doi "https://doi.org/10.1111/j.1525-1373.2000.22407.x" @default.
• W4233265714 hasPublicationYear "2008" @default.
• W4233265714 type Work @default.
• W4233265714 citedByCount "2" @default.
• W4233265714 countsByYear W42332657142020 @default.
• W4233265714 crossrefType "journal-article" @default.
• W4233265714 hasAuthorship W4233265714A5002183495 @default.
• W4233265714 hasAuthorship W4233265714A5003220233 @default.
• W4233265714 hasAuthorship W4233265714A5008400314 @default.
• W4233265714 hasAuthorship W4233265714A5009328617 @default.
• W4233265714 hasAuthorship W4233265714A5026002617 @default.
• W4233265714 hasAuthorship W4233265714A5047868880 @default.
• W4233265714 hasConcept C12519072 @default.
• W4233265714 hasConcept C142462285 @default.
• W4233265714 hasConcept C153911025 @default.
• W4233265714 hasConcept C163421366 @default.
• W4233265714 hasConcept C173358068 @default.
• W4233265714 hasConcept C181199279 @default.
• W4233265714 hasConcept C190283241 @default.
• W4233265714 hasConcept C193349765 @default.
• W4233265714 hasConcept C203014093 @default.
• W4233265714 hasConcept C2775998712 @default.
• W4233265714 hasConcept C2776714187 @default.
• W4233265714 hasConcept C2781143361 @default.
• W4233265714 hasConcept C28859421 @default.
• W4233265714 hasConcept C29311851 @default.
• W4233265714 hasConcept C2993143319 @default.
• W4233265714 hasConcept C3013748606 @default.
• W4233265714 hasConcept C31573885 @default.
• W4233265714 hasConcept C55493867 @default.
• W4233265714 hasConcept C86803240 @default.
• W4233265714 hasConcept C95444343 @default.
• W4233265714 hasConcept C98424977 @default.
• W4233265714 hasConceptScore W4233265714C12519072 @default.
• W4233265714 hasConceptScore W4233265714C142462285 @default.
• W4233265714 hasConceptScore W4233265714C153911025 @default.
• W4233265714 hasConceptScore W4233265714C163421366 @default.
• W4233265714 hasConceptScore W4233265714C173358068 @default.
• W4233265714 hasConceptScore W4233265714C181199279 @default.
• W4233265714 hasConceptScore W4233265714C190283241 @default.
• W4233265714 hasConceptScore W4233265714C193349765 @default.
• W4233265714 hasConceptScore W4233265714C203014093 @default.
• W4233265714 hasConceptScore W4233265714C2775998712 @default.
• W4233265714 hasConceptScore W4233265714C2776714187 @default.
• W4233265714 hasConceptScore W4233265714C2781143361 @default.
• W4233265714 hasConceptScore W4233265714C28859421 @default.
• W4233265714 hasConceptScore W4233265714C29311851 @default.
• W4233265714 hasConceptScore W4233265714C2993143319 @default.
• W4233265714 hasConceptScore W4233265714C3013748606 @default.
• W4233265714 hasConceptScore W4233265714C31573885 @default.
• W4233265714 hasConceptScore W4233265714C55493867 @default.

• next