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• W4233274906 abstract "BACKGROUND Cutaneous metastatic disease is an important finding that may represent the first sign of systemic cancer, or, if already known, that may change tumor staging and thus dramatically altered therapeutic plans. Although cutaneous metastases are relatively frequent in patients with cutaneous melanoma, they are less so from ocular melanoma. OBJECTIVE To demonstrate the value of HMB-45, staining in the detection of ocular melanoma metastatic to skin. METHODS The immunohistochemical stain HMB-45 a monoclonal antibody directed against intact human melanoma cells, was employed on a skin biopsy specimen from a cutaneous tumor. RESULTS HMB-45 staining was positive in the atypical hyperchromatic cells of the deep dermis. CONCLUSION HMB-45 may be of value in the detection of ocular melanoma metastatic to skin. Cutaneous metastatic disease is a somewhat common and extremely important diagnosis. Although cutaneous metastases from cutaneous melanoma are relatively frequent, those from ocular melanomas are less so. Use of histochemical staining, especially the HMB-45 stain, allows confirmation of the diagnosis." @default.
• W4233274906 created "2022-05-12" @default.
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• W4233274906 date "2004-06-01" @default.
• W4233274906 modified "2023-10-14" @default.
• W4233274906 title "Ocular Melanoma Metastatic to Skin" @default.
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• W4233274906 doi "https://doi.org/10.1097/00042728-200406000-00028" @default.
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