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- W4233313377 abstract "In our previous studies, CTL that were sensitive to low concentrations of peptide Ag were found to be far superior to those requiring high concentrations of Ag for reducing viral burden when adoptively transferred into SCID mice. Thus it is important that we understand the mechanisms that control the requirement for peptide Ag with the long-term goal of selectively expanding these exquisitely sensitive cells in vivo. Although TCR affinity is one parameter that can affect the CTL sensitivity for Ag, we investigated whether additional mechanisms may also be involved. In studies using a TCR transgenic mouse model, we successfully generated CTL with identical TCR affinity that possess distinctly different activation requirements. Using both peptide Ag and anti-CD3 Ab to activate the CTL lines of high vs low avidity, we found that the variations in activation threshold are the result of differences in the required number of engaged TCR. Additionally, we have observed that the ratio of CD8αβ to CD8αα is significantly greater in CTL lines that are more sensitive to TCR engagement, which may contribute to the lower activation threshold of these CTL following CD3 engagement. These studies identify a novel mechanism by which the activation requirements of Ag-specific CTL are determined by demonstrating a direct correlation between the sensitivity to TCR engagement, the expression of levels CD8αβ vs αα, and the amount of peptide Ag required to reach the threshold for activation." @default.
- W4233313377 created "2022-05-12" @default.
- W4233313377 creator A5054780081 @default.
- W4233313377 creator A5074817491 @default.
- W4233313377 date "2015-11-19" @default.
- W4233313377 modified "2023-09-27" @default.
- W4233313377 title "Clinical round-up" @default.
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- W4233313377 doi "https://doi.org/10.1136/sextrans-2015-052257" @default.
- W4233313377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26900616" @default.
- W4233313377 hasPublicationYear "2015" @default.
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