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- W4233350613 abstract "Electron spin resonance (ESR) spectroscopy has been used to investigate free radical generation in rats with acute methanol poisoning. The spin trapping technique was used where a spin trapping agent, α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), reacted with the corresponding alcohol-derived or alcohol-dependent radical to form radical adducts. One radical adduct was detected in both bile and urine samples 2 h after acute methanol poisoning in male Sprague Dawley rats. The hyperfine coupling constants for the radical adduct from [13C]-labeled methanol detected in the bile were aN = 15.58, aβH = 2.81 G, and aβ13C = 4.53 G, which unambiguously identified this species as POBN/CH2OH. The same radical adduct was detected in urine. The identification of a methanol-derived radical adduct in samples from bile and urine provided strong direct evidence for the generation of the alcohol-derived radicals during acute intoxication by methanol. Simultaneous administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole and methanol resulted in an increase in the generation of the free radical metabolite detected in the bile. This is the first ESR evidence of methanol-derived free radical generation in an animal model of acute methanol intoxication." @default.
- W4233350613 created "2022-05-12" @default.
- W4233350613 date "1992-01-01" @default.
- W4233350613 modified "2023-09-25" @default.
- W4233350613 title "Contents of journals relating to toxicology" @default.
- W4233350613 doi "https://doi.org/10.1016/0300-483x(92)90185-h" @default.
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