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- W4233365629 abstract "This chapter discusses studies focusing on L-DOPA and pancreatic secretion. In the course of comparative studies on the vascular and the functional responses of the isolated blood-perfused organs to various pharmacological agents, it was observed that dopamine stimulated strikingly the exocrine pancreas. Such striking response to dopamine was not observed in any other organ. Because the canine pancreas had its spontaneous secretion even in the fasting state, either stimulation or inhibition could be readily observed when substances were injected intra-arterially. The specificity of dopamine as a secretagogue of the exocrine pancreas was confirmed when effects of various biogenic and foreign substances were compared on the pancreatic secretion in the resting state. Among sympathomimetic amines tested, that is, dopamine, noradrenaline, adrenaline, isoprenaline, phenylephrine, methoxamine, ephedrine, tyramine, epinine, α-methyldopamine and 6-hydroxydopamine, only dopamine and 6-hydroxydopamine stimulated the secretion, but the latter was far less active than the former. The results suggest that the L-dopa is taken up across the membrane of the exocrine pancreas cell and is converted to dopamine by dopa decarboxylase in the cytoplasm." @default.
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- W4233365629 date "1973-01-01" @default.
- W4233365629 modified "2023-09-25" @default.
- W4233365629 title "L-DOPA AND PANCREATIC SECRETION" @default.
- W4233365629 doi "https://doi.org/10.1016/b978-0-08-017922-3.50157-x" @default.
- W4233365629 hasPublicationYear "1973" @default.
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