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- W4233368557 abstract "This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review will investigate all infants of less than 28 days corrected age who are ventilated with intermittent positive pressure ventilation. The primary objectives are to determine: Whether the use of volume‐targeted (VT) ventilation strategies compared with time‐cycled pressure‐limited ventilation reduces rates of mortality and bronchopulmonary dysplasia. In addition these strategies will be compared to determine any differences in the incidences of complications of prematurity and adverse neurological outcomes. Subgroup analyses Three subgroup analyses are planned based on: 1. mode of volume‐targeted ventilation 2. age at recruitment into study 3. maturity / birth weight of the infants 1. In view of the differences between the two modes of volume‐targeted ventilation the following subgroup comparisons will be made: i) Volume‐controlled ventilation compared with time‐cycled, pressure‐limited ventilation ii) Volume guarantee ventilation compared with time‐cycled, pressure‐limited ventilation 2. Subgroups will also be defined according to postnatal age at time of recruitment into studies: i) Early recruitment, i.e. commencement of ventilation strategy at birth or within the first four hours of life ii) Late recruitment, i.e. beyond 4 hours of age. This subgroup will include trials in which volume ventilation is tested as a rescue strategy 3. In view of the increased incidence of BPD in the smallest, most immature infants, subgroups will also be defined according to: i) Birth weight, with a cut‐off of around 1000g ii) Gestational age, with a cut‐off of around 30 weeks' gestation" @default.
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- W4233368557 date "2002-04-22" @default.
- W4233368557 modified "2023-09-26" @default.
- W4233368557 title "Volume-targeted versus pressure-limited ventilation in the neonate" @default.
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- W4233368557 doi "https://doi.org/10.1002/14651858.cd003666" @default.
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