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- W4233382014 abstract "Tauopathies are an important class of neurodegenerative disorders, including progressive supranuclear palsy syndrome (PSPS), corticobasal syndrome (CBS), and some forms of Frontotemporal Lobar Degeneration (FTLD) (ie. FTLD-Tau) that present clinically as variants of Frontotemporal Dementia (FTD) (see methods) A major challenge for treating tauopathy is early diagnosis and accurate discrimination among different tauopathies. Our main goal was to compare a novel diffusion tensor imaging (DTI) analysis of the cortical architecture of tauopathy with other standard measures and to test its power to discriminate between different tauopathies. 24 healthy controls, 17 semantic-variant FTD (sv-FTD), 15 behavioural-variant (bvFTD), 10 progressive non-fluent aphasia (PNFA), 16 PSPS and 11 CBS cases were included. For each subject, 3T MRI T1 weighted images and DTI scans were analyzed to extract novel DTI-derived measures (Cortical-disarray-measurement angle CDM_A, perpendicular CDM_PERP and parallel CDM_PAR) and mean diffusivity, as well as standard volumetric measurements. Whole brain and sub-regional data were extracted. Cognitive scores were also compared for these subjects (MOCA, MMSE). Receiver Operating Characteristics (ROC) curve analysis was used to assess group discrimination capabilities of cognitive, volumetric and DTI measures (area under the curve, sensitivity, specificity, accuracy, positive and negative predictive values). CDM_A was the best feature to distinguish between controls and all patients (highest AUC), and between controls and FTD groups. CDM_PAR was the best feature to distinguish between controls and PSPS, also between controls and CBS, and between FTD groups and PSPS. 1. From the set of cognitive measures, and whole brain MRI measurements of volume and cortical diffusion measurements, CDM_A achieved the highest classification power for differentiating tauopathies from healthy controls. 2. Novel cortical diffusion measurements (eg. CDM_PAR) could provide further differential markers to identify PSPS and CBS and to distinguish PSPS from FTD groups." @default.
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- W4233382014 date "2019-07-01" @default.
- W4233382014 modified "2023-10-06" @default.
- W4233382014 title "P1-365: DIFFERENTIATING TAUOPATHIES WITH A NOVEL DIFFUSION TENSOR IMAGING METHOD TO INVESTIGATE CORTICAL ARCHITECTURE" @default.
- W4233382014 doi "https://doi.org/10.1016/j.jalz.2019.06.920" @default.
- W4233382014 hasPublicationYear "2019" @default.
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