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- W4233429131 abstract "What's already known about this topic? Genetic sonogram has been in existence for over 20°years, and the approach is used by many centers for prenatal screening for Down syndrome. Scoring systems to grade genetic sonographic markers are a coarse and obsolete way to utilize genetic sonograms. What does this review add? Use of likelihood ratios or formulas derived from logistic regression analysis is the optimal model to incorporate genetic sonogram findings into prior probability to calculate posterior probabilities of Down syndrome. Although mathematical models suggest that genetic sonogram may add significantly to the information provided by first-trimester screening, validation studies have not confirmed the finding. The genetic sonogram will continue to have a place in the era of cell-free DNA testing, particularly in twin and higher-order multiples, in countries with limited access to the recent advances in genetic screening, and for women with borderline or no results at cell-free DNA testing." @default.
- W4233429131 created "2022-05-12" @default.
- W4233429131 date "2014-06-01" @default.
- W4233429131 modified "2023-09-23" @default.
- W4233429131 doi "https://doi.org/10.1002/pd.v34.6" @default.
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