Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233505357> ?p ?o ?g. }
- W4233505357 endingPage "878" @default.
- W4233505357 startingPage "870" @default.
- W4233505357 abstract "Cytokine receptors have been shown in cell culture systems to use phosphotyrosine residues as docking sites for certain signal transduction intermediates. Studies using various cellular backgrounds have yielded conflicting information about the importance of such residues. The present studies were undertaken to determine whether or not tyrosine residues within the erythropoietin receptor (EPOR) are essential for biologic activity during hematopoiesis in vivo. A variant of the EPOR was constructed that contains both a substitution (R129C) causing constitutive receptor activation as well as replacement of all eight cytoplasmic tyrosines by phenylalanines (cEPORYF). A comparison between animals exposed to recombinant retroviruses expressing cEPOR and cEPORYF showed that efficient red blood cell (RBC) development in vivo is dependent on the presence of tyrosine residues in the cytoplasmic domain of the EPOR. In addition, an inefficient EPOR tyrosine independent pathway supporting RBC development was detected. Tyrosine add-back mutants showed that multiple individual tyrosines have the capacity to restore full erythropoietic potential to the EPOR as determined in whole animals. The analysis of primary erythroid progenitors transduced with the various cEPOR tyrosine mutants and tyrosine add-backs showed that only tyrosine 343 (Y1) and tyrosine 479 (Y8) were capable of supporting immature burst-forming unit–erythroid progenitor development. Thus, this receptor is characterized by striking functional redundancy of tyrosines in a biologically relevant context. However, selective tyrosine residues may be uniquely important for early signals supporting erythroid development." @default.
- W4233505357 created "2022-05-12" @default.
- W4233505357 creator A5021689661 @default.
- W4233505357 creator A5043524525 @default.
- W4233505357 creator A5047529722 @default.
- W4233505357 creator A5051129068 @default.
- W4233505357 creator A5066441344 @default.
- W4233505357 creator A5081622824 @default.
- W4233505357 creator A5086386726 @default.
- W4233505357 creator A5088714641 @default.
- W4233505357 date "1998-02-01" @default.
- W4233505357 modified "2023-10-01" @default.
- W4233505357 title "Redundant and Selective Roles for Erythropoietin Receptor Tyrosines in Erythropoiesis In Vivo" @default.
- W4233505357 cites W1482774511 @default.
- W4233505357 cites W1564510779 @default.
- W4233505357 cites W1568906555 @default.
- W4233505357 cites W1578727637 @default.
- W4233505357 cites W1606072873 @default.
- W4233505357 cites W1640663936 @default.
- W4233505357 cites W1900781903 @default.
- W4233505357 cites W1966923743 @default.
- W4233505357 cites W1972927903 @default.
- W4233505357 cites W1972941866 @default.
- W4233505357 cites W1987251111 @default.
- W4233505357 cites W2009857536 @default.
- W4233505357 cites W2012505338 @default.
- W4233505357 cites W2013032587 @default.
- W4233505357 cites W2018574052 @default.
- W4233505357 cites W2020337983 @default.
- W4233505357 cites W2033753214 @default.
- W4233505357 cites W2046986081 @default.
- W4233505357 cites W2054918661 @default.
- W4233505357 cites W2062706326 @default.
- W4233505357 cites W2065549220 @default.
- W4233505357 cites W2065577646 @default.
- W4233505357 cites W2068499309 @default.
- W4233505357 cites W2071467130 @default.
- W4233505357 cites W2076838680 @default.
- W4233505357 cites W2093602531 @default.
- W4233505357 cites W2122601432 @default.
- W4233505357 cites W2125753847 @default.
- W4233505357 cites W2128565119 @default.
- W4233505357 cites W2137333423 @default.
- W4233505357 cites W2159799155 @default.
- W4233505357 cites W233692421 @default.
- W4233505357 cites W2408546921 @default.
- W4233505357 cites W2414190385 @default.
- W4233505357 cites W2414854471 @default.
- W4233505357 cites W4254938972 @default.
- W4233505357 cites W4256003647 @default.
- W4233505357 doi "https://doi.org/10.1182/blood.v91.3.870.870_870_878" @default.
- W4233505357 hasPublicationYear "1998" @default.
- W4233505357 type Work @default.
- W4233505357 citedByCount "1" @default.
- W4233505357 crossrefType "journal-article" @default.
- W4233505357 hasAuthorship W4233505357A5021689661 @default.
- W4233505357 hasAuthorship W4233505357A5043524525 @default.
- W4233505357 hasAuthorship W4233505357A5047529722 @default.
- W4233505357 hasAuthorship W4233505357A5051129068 @default.
- W4233505357 hasAuthorship W4233505357A5066441344 @default.
- W4233505357 hasAuthorship W4233505357A5081622824 @default.
- W4233505357 hasAuthorship W4233505357A5086386726 @default.
- W4233505357 hasAuthorship W4233505357A5088714641 @default.
- W4233505357 hasBestOaLocation W42335053571 @default.
- W4233505357 hasConcept C101544691 @default.
- W4233505357 hasConcept C126322002 @default.
- W4233505357 hasConcept C134018914 @default.
- W4233505357 hasConcept C170493617 @default.
- W4233505357 hasConcept C197153747 @default.
- W4233505357 hasConcept C2776165026 @default.
- W4233505357 hasConcept C2777553839 @default.
- W4233505357 hasConcept C2778248108 @default.
- W4233505357 hasConcept C2778534260 @default.
- W4233505357 hasConcept C2779703530 @default.
- W4233505357 hasConcept C31102739 @default.
- W4233505357 hasConcept C55493867 @default.
- W4233505357 hasConcept C62478195 @default.
- W4233505357 hasConcept C71924100 @default.
- W4233505357 hasConcept C86803240 @default.
- W4233505357 hasConcept C95444343 @default.
- W4233505357 hasConceptScore W4233505357C101544691 @default.
- W4233505357 hasConceptScore W4233505357C126322002 @default.
- W4233505357 hasConceptScore W4233505357C134018914 @default.
- W4233505357 hasConceptScore W4233505357C170493617 @default.
- W4233505357 hasConceptScore W4233505357C197153747 @default.
- W4233505357 hasConceptScore W4233505357C2776165026 @default.
- W4233505357 hasConceptScore W4233505357C2777553839 @default.
- W4233505357 hasConceptScore W4233505357C2778248108 @default.
- W4233505357 hasConceptScore W4233505357C2778534260 @default.
- W4233505357 hasConceptScore W4233505357C2779703530 @default.
- W4233505357 hasConceptScore W4233505357C31102739 @default.
- W4233505357 hasConceptScore W4233505357C55493867 @default.
- W4233505357 hasConceptScore W4233505357C62478195 @default.
- W4233505357 hasConceptScore W4233505357C71924100 @default.
- W4233505357 hasConceptScore W4233505357C86803240 @default.
- W4233505357 hasConceptScore W4233505357C95444343 @default.
- W4233505357 hasIssue "3" @default.
- W4233505357 hasLocation W42335053571 @default.