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• W4233510602 startingPage "129" @default.
• W4233510602 abstract "Multidrug-resistant tuberculosis (MDR-TB), caused by Mycobacterium tuberculosis strains resistant to at least isoniazid (INH) and rifampin (1), is difficult to treat effectively and requires medications that are expensive, toxic, and less effective than first-line anti-TB therapy. In March 2006 the original definition of extensively drug-resistant TB (XDR-TB) was reported in the CDC's Morbidity and Mortality Weekly Report (2). In October of the same year a revised definition was reported: XDR-TB is defined as TB resistant to INH, rifampin, a second-line injectable drug (SLID; kanamycin, amikacin, or capreomycin), and any fluoroquinolone (3). This new definition was better able to identify a group with worse outcomes, including higher mortality rates, than with MDR-TB (4). MDR- and XDR-TB strains are resistant to the most potent anti-TB medications that are reliably associated with successful outcomes. The outbreak of MDR-TB in New York City in the 1990s caught the world's attention, as has the rapid spread of XDR-TB globally (5 - 7)." @default.
• W4233510602 created "2022-05-12" @default.
• W4233510602 creator A5026721347 @default.
• W4233510602 creator A5074399838 @default.
• W4233510602 date "2017-04-27" @default.
• W4233510602 modified "2023-10-18" @default.
• W4233510602 title "Therapy of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis" @default.
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