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- W4233524373 abstract "Losartan is a nonpeptide angiotensin II receptor antagonist used for the treatment of hypertension. The in vitro metabolism of losartan was investigated in incubations with liver slice preparations from rats, monkeys, and humans. Incubation of losartan with human liver slices formed six metabolites of similar quantity. The aliphatic hydroxylation at various positions yielded three metabolites. Oxidation of the parent hydroxymethyl moiety yielded the corresponding acid, which was postulated via the aldehyde intermediate. The acid metabolite was found to be more potent than losartan as a nonpeptide angiotensin II receptor antagonist. It formed further an N ‐glucuronide conjugate." @default.
- W4233524373 created "2022-05-12" @default.
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- W4233524373 date "2013-10-13" @default.
- W4233524373 modified "2023-09-26" @default.
- W4233524373 title "Losartan" @default.
- W4233524373 cites W2010652803 @default.
- W4233524373 doi "https://doi.org/10.1002/9781118541203.xen205" @default.
- W4233524373 hasPublicationYear "2013" @default.
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