Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233546327> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4233546327 abstract "<b>Objective: </b>Reports of amputations associated with sodium glucose co-transporter (SGLT) 2 inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase (DPP)-4 inhibitors among patients with type 2 diabetes. <p><b>Research Design and Methods:</b> This is a multicenter observational study using administrative healthcare databases from 7 Canadian provinces and the United Kingdom. Incident SGLT2 inhibitor users were matched to DPP-4 inhibitor users using a prevalent new user design and time-conditional propensity scores. Cox proportional hazards models were used to estimate site-specific adjusted hazard ratios (HR) and corresponding 95% confidence intervals (CI) of incident below-knee amputation for SGLT2 inhibitor versus DPP-4 inhibitor users. Random effects meta-analyses were used to pool the site-specific results.</p> <p><b>Results:</b> The study cohort included 207,817 incident SGLT2 inhibitor users matched to 207,817 DPP-4 inhibitor users. During a mean exposed follow up time of 11 months, the amputation rate among SGLT2 inhibitor users was 1.3 per 1,000 person-years and 1.5 per 1,000 person-years among DPP-4 inhibitor users. The adjusted HR of below-knee amputations associated with SGLT2 inhibitor use compared to DPP-4 inhibitor use was 0.88 (95% CI: 0.71-1.09). Similar results were obtained in stratified analyses by specific SGLT2 inhibitor molecule.</p> <p><b>Conclusions: </b>In this large multicenter observational study, there was no association between SGLT2 inhibitor use and incident below-knee amputations among patients with type 2 diabetes, compared to DPP-4 inhibitor use. While these findings provide some reassurance, studies with longer duration of follow-up are needed to assess potential long-term effects.</p>" @default.
- W4233546327 created "2022-05-12" @default.
- W4233546327 creator A5002024158 @default.
- W4233546327 creator A5007497866 @default.
- W4233546327 creator A5017432882 @default.
- W4233546327 creator A5029870762 @default.
- W4233546327 creator A5039987563 @default.
- W4233546327 creator A5042574911 @default.
- W4233546327 creator A5042964192 @default.
- W4233546327 creator A5048225022 @default.
- W4233546327 creator A5057724042 @default.
- W4233546327 creator A5068337009 @default.
- W4233546327 creator A5072519261 @default.
- W4233546327 creator A5081987341 @default.
- W4233546327 creator A5082999537 @default.
- W4233546327 creator A5087573242 @default.
- W4233546327 creator A5089776227 @default.
- W4233546327 date "2020-08-05" @default.
- W4233546327 modified "2023-10-16" @default.
- W4233546327 title "Sodium Glucose Co-transporter-2 Inhibitors and the Risk of Below-knee Amputation: a Multicenter Observational Study" @default.
- W4233546327 doi "https://doi.org/10.2337/figshare.12652454" @default.
- W4233546327 hasPublicationYear "2020" @default.
- W4233546327 type Work @default.
- W4233546327 citedByCount "0" @default.
- W4233546327 crossrefType "posted-content" @default.
- W4233546327 hasAuthorship W4233546327A5002024158 @default.
- W4233546327 hasAuthorship W4233546327A5007497866 @default.
- W4233546327 hasAuthorship W4233546327A5017432882 @default.
- W4233546327 hasAuthorship W4233546327A5029870762 @default.
- W4233546327 hasAuthorship W4233546327A5039987563 @default.
- W4233546327 hasAuthorship W4233546327A5042574911 @default.
- W4233546327 hasAuthorship W4233546327A5042964192 @default.
- W4233546327 hasAuthorship W4233546327A5048225022 @default.
- W4233546327 hasAuthorship W4233546327A5057724042 @default.
- W4233546327 hasAuthorship W4233546327A5068337009 @default.
- W4233546327 hasAuthorship W4233546327A5072519261 @default.
- W4233546327 hasAuthorship W4233546327A5081987341 @default.
- W4233546327 hasAuthorship W4233546327A5082999537 @default.
- W4233546327 hasAuthorship W4233546327A5087573242 @default.
- W4233546327 hasAuthorship W4233546327A5089776227 @default.
- W4233546327 hasBestOaLocation W42335463271 @default.
- W4233546327 hasConcept C126322002 @default.
- W4233546327 hasConcept C134018914 @default.
- W4233546327 hasConcept C141071460 @default.
- W4233546327 hasConcept C156490143 @default.
- W4233546327 hasConcept C201903717 @default.
- W4233546327 hasConcept C207103383 @default.
- W4233546327 hasConcept C23131810 @default.
- W4233546327 hasConcept C2776204877 @default.
- W4233546327 hasConcept C2777180221 @default.
- W4233546327 hasConcept C2779668873 @default.
- W4233546327 hasConcept C44249647 @default.
- W4233546327 hasConcept C50382708 @default.
- W4233546327 hasConcept C555293320 @default.
- W4233546327 hasConcept C71924100 @default.
- W4233546327 hasConcept C98274493 @default.
- W4233546327 hasConceptScore W4233546327C126322002 @default.
- W4233546327 hasConceptScore W4233546327C134018914 @default.
- W4233546327 hasConceptScore W4233546327C141071460 @default.
- W4233546327 hasConceptScore W4233546327C156490143 @default.
- W4233546327 hasConceptScore W4233546327C201903717 @default.
- W4233546327 hasConceptScore W4233546327C207103383 @default.
- W4233546327 hasConceptScore W4233546327C23131810 @default.
- W4233546327 hasConceptScore W4233546327C2776204877 @default.
- W4233546327 hasConceptScore W4233546327C2777180221 @default.
- W4233546327 hasConceptScore W4233546327C2779668873 @default.
- W4233546327 hasConceptScore W4233546327C44249647 @default.
- W4233546327 hasConceptScore W4233546327C50382708 @default.
- W4233546327 hasConceptScore W4233546327C555293320 @default.
- W4233546327 hasConceptScore W4233546327C71924100 @default.
- W4233546327 hasConceptScore W4233546327C98274493 @default.
- W4233546327 hasLocation W42335463271 @default.
- W4233546327 hasLocation W42335463272 @default.
- W4233546327 hasLocation W42335463273 @default.
- W4233546327 hasOpenAccess W4233546327 @default.
- W4233546327 hasPrimaryLocation W42335463271 @default.
- W4233546327 hasRelatedWork W2026094606 @default.
- W4233546327 hasRelatedWork W2071306276 @default.
- W4233546327 hasRelatedWork W2084774262 @default.
- W4233546327 hasRelatedWork W2132123983 @default.
- W4233546327 hasRelatedWork W2170298832 @default.
- W4233546327 hasRelatedWork W2611840721 @default.
- W4233546327 hasRelatedWork W2624186596 @default.
- W4233546327 hasRelatedWork W2760462550 @default.
- W4233546327 hasRelatedWork W2801904771 @default.
- W4233546327 hasRelatedWork W4308469642 @default.
- W4233546327 isParatext "false" @default.
- W4233546327 isRetracted "false" @default.
- W4233546327 workType "article" @default.