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- W4233559095 abstract "In Bordetella pertussis virulence-associated genes, including adenylate cyclase toxin (Cya), are coordinately regulated in response to environmental signals by proteins coded by the bvg-locus. We have constructed cya-lac fusions in Escherichia coli and have shown that the cya operon is not expressed in E. coli, neither is it activated by bvg, when introduced in trans. The cya-lac fusion is fully active when returned to B. pertussis by homologous recombination and responds to bvg-dependent activation and environmental regulation. These results indicate that in B. pertussis the activation of the cya operon by bvg is indirect." @default.
- W4233559095 created "2022-05-12" @default.
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- W4233559095 date "1991-01-15" @default.
- W4233559095 modified "2023-09-25" @default.
- W4233559095 title "Analysis of Bordetella pertussis cya operon regulation by use of cya-lac fusions" @default.
- W4233559095 doi "https://doi.org/10.1016/0378-1097(91)90561-n" @default.
- W4233559095 hasPublicationYear "1991" @default.
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