FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233604369> ?p ?o ?g. }

• W4233604369 endingPage "2349" @default.
• W4233604369 startingPage "2335" @default.
• W4233604369 abstract "Nerve growth factor (NGF) plays a critical role in the development and survival of neurons in the peripheral nervous system. Following treatment with NGF but not epidermal growth factor, rat pheochromocytoma (PC12) cells undergo neural differentiation. We have cloned a nervous system-specific mRNA, NGF33.1, that is rapidly and relatively selectively induced by treatment of PC12 cells with NGF and basic fibroblast growth factor in comparison with epidermal growth factor. Analysis of the nucleic acid and predicted amino acid sequences of the NGF33.1 cDNA clone suggested that this clone corresponded to the NGF-inducible mRNA called VGF (A. Levi, J. D. Eldridge, and B. M. Paterson, Science 229:393-395, 1985; R. Possenti, J. D. Eldridge, B. M. Paterson, A. Grasso, and A. Levi, EMBO J. 8:2217-2223, 1989). We have used the NGF33.1 cDNA clone to isolate and characterize the VGF gene, and in this paper we report the complete sequence of the VGF gene, including 853 bases of 5' flank revealed TATAA and CCAAT elements, several GC boxes, and a consensus cyclic AMP response element-binding protein binding site. The VGF promoter contains sequences homologous to other NGF-inducible, neuronal promoters. We further show that VGF mRNA is induced in PC12 cells to a greater extent by depolarization and by phorbol-12-myristate-13-acetate treatment than by 8-bromo-cyclic AMP treatment. By Northern (RNA) and RNase protection analysis, VGF mRNA is detectable in embryonic and postnatal central and peripheral nervous tissues but not in a number of nonneural tissues. In the cascade of events which ultimately leads to the neural differentiation of NGF-treated PC12 cells, the VGF gene encodes the most rapidly and selectively regulated, nervous-system specific mRNA yet identified." @default.
• W4233604369 created "2022-05-12" @default.
• W4233604369 creator A5018894122 @default.
• W4233604369 creator A5020280521 @default.
• W4233604369 creator A5037725557 @default.
• W4233604369 date "1991-05-01" @default.
• W4233604369 modified "2023-09-27" @default.
• W4233604369 title "Structure of the Gene Encoding VGF, a Nervous System-Specific mRNA That Is Rapidly and Selectively Induced by Nerve Growth Factor in PC12 Cells" @default.
• W4233604369 cites W1497202706 @default.
• W4233604369 cites W1504501988 @default.
• W4233604369 cites W1517074681 @default.
• W4233604369 cites W1518058757 @default.
• W4233604369 cites W1527035699 @default.
• W4233604369 cites W1527744735 @default.
• W4233604369 cites W1582530932 @default.
• W4233604369 cites W1583894029 @default.
• W4233604369 cites W1605704996 @default.
• W4233604369 cites W16259457 @default.
• W4233604369 cites W1634432451 @default.
• W4233604369 cites W1848000149 @default.
• W4233604369 cites W1942708553 @default.
• W4233604369 cites W1964831845 @default.
• W4233604369 cites W1969349734 @default.
• W4233604369 cites W1970587959 @default.
• W4233604369 cites W1973921994 @default.
• W4233604369 cites W1975304761 @default.
• W4233604369 cites W1977707793 @default.
• W4233604369 cites W1984676113 @default.
• W4233604369 cites W1984767179 @default.
• W4233604369 cites W1985300178 @default.
• W4233604369 cites W1985770805 @default.
• W4233604369 cites W1987793678 @default.
• W4233604369 cites W1988568219 @default.
• W4233604369 cites W1989825490 @default.
• W4233604369 cites W1990493528 @default.
• W4233604369 cites W1992785510 @default.
• W4233604369 cites W1993214904 @default.
• W4233604369 cites W1993646910 @default.
• W4233604369 cites W1993952760 @default.
• W4233604369 cites W1994852189 @default.
• W4233604369 cites W1996794195 @default.
• W4233604369 cites W2000324336 @default.
• W4233604369 cites W2000359435 @default.
• W4233604369 cites W2000760222 @default.
• W4233604369 cites W2001026574 @default.
• W4233604369 cites W2003102216 @default.
• W4233604369 cites W2005150284 @default.
• W4233604369 cites W2005934192 @default.
• W4233604369 cites W2014669590 @default.
• W4233604369 cites W2015379420 @default.
• W4233604369 cites W2015772561 @default.
• W4233604369 cites W2016773845 @default.
• W4233604369 cites W2017883686 @default.
• W4233604369 cites W2021235665 @default.
• W4233604369 cites W2023328534 @default.
• W4233604369 cites W2024422266 @default.
• W4233604369 cites W2028956297 @default.
• W4233604369 cites W2030380478 @default.
• W4233604369 cites W2037753946 @default.
• W4233604369 cites W2039034666 @default.
• W4233604369 cites W2041639550 @default.
• W4233604369 cites W2041951812 @default.
• W4233604369 cites W2042976701 @default.
• W4233604369 cites W2043254293 @default.
• W4233604369 cites W2043530776 @default.
• W4233604369 cites W2047036794 @default.
• W4233604369 cites W2048033603 @default.
• W4233604369 cites W2052226492 @default.
• W4233604369 cites W2052537645 @default.
• W4233604369 cites W2055540751 @default.
• W4233604369 cites W2058650902 @default.
• W4233604369 cites W2059325872 @default.
• W4233604369 cites W2059433193 @default.
• W4233604369 cites W2060645936 @default.
• W4233604369 cites W2061075846 @default.
• W4233604369 cites W2061236267 @default.
• W4233604369 cites W2061614747 @default.
• W4233604369 cites W2061624786 @default.
• W4233604369 cites W2061983703 @default.
• W4233604369 cites W2064598711 @default.
• W4233604369 cites W2065538605 @default.
• W4233604369 cites W2071140879 @default.
• W4233604369 cites W207372356 @default.
• W4233604369 cites W2074563618 @default.
• W4233604369 cites W2075796579 @default.
• W4233604369 cites W2075943597 @default.
• W4233604369 cites W2078146089 @default.
• W4233604369 cites W2079002609 @default.
• W4233604369 cites W2080125844 @default.
• W4233604369 cites W2080532845 @default.
• W4233604369 cites W2080639744 @default.
• W4233604369 cites W2085516075 @default.
• W4233604369 cites W2088986997 @default.
• W4233604369 cites W2091011317 @default.
• W4233604369 cites W2091222457 @default.
• W4233604369 cites W2092526636 @default.
• W4233604369 cites W2097128116 @default.
• W4233604369 cites W2112365969 @default.

• next