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- W4233634281 abstract "Abstract BackgroundIn neurosurgery, it is important to use local hemostatic agents. We have explored a more powerful method of hemostasis by the combination of commercially available hemostatic agents with fibrin glue in the hopes of synergistic effects.MethodA bleeding model was constructed by puncturing the rabbit posterior vena cava with a needle. After applying the sample to the bleeding point, compression was performed for 10 seconds. If temporary hemostasis was achieved after pressure release, a 30 second wash was performed to confirm that ultimate hemostasis was achieved. Up to three hemostasis attempts were performed on the same bleeding point until hemostasis was achieved, and the number of attempts required for hemostasis was counted. If hemostasis was not achieved after three attempts, it was counted as four times. Four groups were evaluated: (1) gelatin sponge alone, (2) gelatin sponge + fibrin glue, (3) oxidized cellulose alone, and (4) oxidized cellulose + fibrin glue; each group was tested 16 times.ResultsThe median value (range minimum value–maximum value) of the number of hemostatic attempts in Group 1 to Group 4 was 3 (1–4), 1 (1–1), 4 (4–4), and 4 (2–4). In Group 2, there were two test exclusions owing to deviations of the test procedure.ConclusionsThe compatibility of gelatin sponge and fibrin glue was very good, with a very strong and rapid hemostatic effect compared to other methods, showed its usefulness. This combination method may be effective for a variety of venous hemorrhages in neurosurgery." @default.
- W4233634281 created "2022-05-12" @default.
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- W4233634281 date "2020-10-12" @default.
- W4233634281 modified "2023-10-17" @default.
- W4233634281 title "Evaluation of the Hemostatic Effect of a Combination of Hemostatic Agents and Fibrin Glue in a Rabbit Venous Hemorrhage Model" @default.
- W4233634281 doi "https://doi.org/10.21203/rs.3.rs-90059/v1" @default.
- W4233634281 hasPublicationYear "2020" @default.
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